MRI-detectable nanoparticles: the potential role in the diagnosis of and therapy for chronic kidney disease.
MRI-detectable nanoparticles: the potential role in the diagnosis of and therapy for chronic kidney disease.
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DOI：
10.1053/j.ackd.2013.06.002
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发表时间：
2013-11
影响因子：
2.9
通讯作者：
Bennett KM
中科院分区：
文献类型：
--
作者：
Charlton JR;Beeman SC;Bennett KM
Chronic kidney disease (CKD) is a common, deadly, and expensive threat to public health. Patients susceptible to the development of CKD are difficult to identify, as there are few noninvasive clinical techniques and markers to assess early kidney dysfunction. Noninvasive imaging techniques are being developed to quantitatively measure renal morphology and function, both in preclinical research and in clinical trials. Magnetic resonance imaging (MRI) techniques in particular have the potential to provide both structural and functional information in the kidney. Novel molecular imaging techniques, using targeted magnetic nanoparticles that exploit the characteristics of the endogenous protein, ferritin, have been developed in conjunction with MRI to count every perfused glomerulus in the kidney and measure their individual volumes. This technique could open the door to the possibility of prospectively assessing and eventually reducing a patient’s risk for progression to CKD. This review highlights the potential clinical benefits of early detection in patients predisposed to CKD and discusses technologic and regulatory hurdles to the translation of these molecular MRI techniques to provide early diagnosis of CKD.
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