The airway epithelium during infancy and childhood: A complex multicellular immune barrier. Basic review for clinicians.
The airway epithelium during infancy and childhood: A complex multicellular immune barrier. Basic review for clinicians.
复制标题
DOI：
10.1016/j.prrv.2021.04.002
复制
发表时间：
2021-06
影响因子：
5.8
通讯作者：
Nino G
中科院分区：
文献类型：
--
作者：
Xu-Chen X;Weinstock J;Rastogi D;Koumbourlis A;Nino G
气道上皮是从鼻咽延伸到小气道的复杂的多细胞层。它在生命早期作为免疫呼吸屏障发挥作用，发育，成熟和再生以适应环境的变化。虽然气道上皮异常已被确定在几个临床疾病，有越来越多的兴趣，了解其在人类的基本调节和结构。事实上，最近的技术进步（例如单细胞分析和新的人类气道上皮细胞模型）使我们能够识别额外的细胞亚型和功能，总体上大大提高了我们对健康和疾病期间气道上皮的理解。在这篇综述中，我们总结了气道上皮的关键特征，包括：1）多层结构和细胞异质性; 2）对不同环境和发育刺激的适应性; 3）先天识别;和4）免疫反应的协调。我们讨论了这些功能的翻译和临床前景，重点是人类呼吸道免疫的发展，特别是在生命早期。
The airway epithelium is a complex multicellular layer that extends from the nasopharynx to the small airways. It functions as an immune respiratory barrier during early life that develops, matures, and regenerates to adapt to the changes in the environment. While airway epithelial abnormalities have been identified in several clinical disorders, there is increasing interest in understanding its basic regulation and structure in humans. Indeed, recent advances in technology (e.g. single-cell analysis and new human airway epithelial cell models) have allowed us to identify additional cellular subtypes and functions that overall have greatly improved our understanding of the airway epithelium during health and disease. In this review we summarize key features of the airway epithelium including: 1) multilayer structure and cell heterogeneity; 2) adaptability to different environmental and developmental stimuli; 3) innate recognition; and 4) orchestration of immune responses. We discuss these features with a translational and clinical prospective focusing on the development of human respiratory immunity, particularly during early life.
登录
查看更多内容
影响因子：
7.3
作者：
Hemann EA;Gale M Jr;Savan R
通讯作者：
Savan R
DOI：
10.4049/jimmunol.1700216
发表时间：
2017-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Han M;Rajput C;Hong JY;Lei J;Hinde JL;Wu Q;Bentley JK;Hershenson MB
通讯作者：
Hershenson MB
DOI：
10.1186/s40413-018-0192-5
发表时间：
2018
期刊：
The World Allergy Organization journal
影响因子：
--
作者：
Caminati M;Pham DL;Bagnasco D;Canonica GW
通讯作者：
Canonica GW
影响因子：
10.4
作者：
BREEZE, R;TURK, M
通讯作者：
TURK, M
影响因子：
9.6
作者：
Jamieson, Kyla C.;Warner, Stephanie M.;Proud, David
通讯作者：
Proud, David