Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice.
Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice.
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DOI：
10.1016/j.yhbeh.2010.07.008
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发表时间：
2010-11
影响因子：
3.5
通讯作者：
Rissman, Emilie F.
中科院分区：
文献类型：
--
作者：
Cox, Kimberly H.;Gatewood, Jessica D.;Howeth, Chelsea;Rissman, Emilie F.
关键词：
双酚 A (BPA) 是聚碳酸酯树脂的一种成分，最近人们开始担心它对人类健康的潜在负面影响。 BPA 是一种雌激素类似物，此外，它还可以充当 DNA 低甲基化剂。我们研究了妊娠期接触 BPA 对 C57BL/6J 小鼠几种行为的影响。由于 BPA 会影响母体护理，进而可能对后代行为产生长期影响，因此我们测试了由亲生或寄养水坝饲养的小鼠。饮食和水坝都会影响幼年小鼠在社交新奇任务和高架十字迷宫（EPM）中的行为。在一项社交新奇任务中，与成年雄性互动的时间会受到性别和妊娠饮食的影响，但仅限于由寄养母亲抚养的幼体。与在妊娠期间暴露于 BPA 的对照雄性或雌性相比，对照组雌性花在嗅新成人上的时间更少。在 EPM 中，与采用对照饮食妊娠的幼鱼相比，由寄养水坝饲养并在妊娠期间接触 BPA 的幼鱼在张开臂的远端半部停留的时间较短。由生物水坝养育的成年后代表现出相同的反应模式。与对照饮食相比，妊娠期 BPA 会增加焦虑。我们的结果表明，产前 BPA 暴露会影响 EPM 的社交行为和焦虑。此外，母婴互动的某些方面可能会改变这些影响。
Bisphenol-A (BPA) is a component of polycarbonate resins, and, lately, concern has been raised about its potential negative effects on human health. BPA is an estrogen analog and, in addition, it can act as a DNA hypomethylator. We examined effects of gestational exposure to BPA on several behaviors in C57BL/6J mice. Because BPA affects maternal care, which, may have long-lasting effects on offspring behavior, we tested mice raised by either biological or fostered dams. Both diet and dam affected behavior in juvenile mice in a social novelty task and the elevated plus maze (EPM). In a social novelty task, the amount of time spent interacting with an adult male was affected by sex and gestational diet, but only in juveniles raised by a foster dam. Control females spent less time sniffing a novel adult than did control males or females exposed to BPA during gestation. In the EPM, juveniles reared by foster dams and exposed to BPA during gestation spent less time in the distal half of the open arm as compared with juveniles gestated on a control diet. Adult offspring raised by their biological dams showed the same response pattern; gestational BPA increased anxiety as compared with control diet. Our results show that prenatal BPA exposure affects social behavior and anxiety in the EPM. Moreover, some facet(s) of the infant-maternal interaction may modify these effects.
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影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
2.9
作者：
Imwalle, DB;Gustafsson, JÅ;Rissman, EF
通讯作者：
Rissman, EF
DOI：
10.1073/pnas.0703739104
发表时间：
2007-08-07
影响因子：
11.1
作者：
Dolinoy, Dana C.;Huang, Dale;Jirtle, Randy L.
通讯作者：
Jirtle, Randy L.
影响因子：
2.9
作者：
Fujimoto, T;Kubo, K;Aou, S
通讯作者：
Aou, S
影响因子：
2.6
作者：
Henderson, ND;Turri, MG;Flint, J
通讯作者：
Flint, J