Aberrant default mode functional connectivity in early onset schizophrenia.
Aberrant default mode functional connectivity in early onset schizophrenia.
复制标题
早发性精神分裂症的异常默认模式功能连接
DOI：
10.1371/journal.pone.0071061
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Tang J;Liao Y;Song M;Gao JH;Zhou B;Tan C;Liu T;Tang Y;Chen J;Chen X
背景默认模式网络（DMN）与包括精神分裂症在内的许多精神障碍有关。然而，在早发性精神分裂症（EOS）中DMN连接异常的报道很少。方法采用独立成分分析（伊卡）方法，对32例首发EOS青少年和32例年龄、性别匹配的健康对照者DMN的功能连接（FC）进行研究。结果与正常对照组相比，EOS患者额内侧回与DMN其他区域之间的FC增加。偏相关分析显示，额内侧回FC与PANSS阳性症状显著相关（偏相关系数= 0.538，Bonferoni校正P = 0.018）。 虽然参与者的样本量与迄今为止的大多数fMRI研究相当，但仍然相对较小。将儿童脑与MNI成人脑模板配准。然而，可能的年龄特异性差异，在空间归一化所产生的注册小儿大脑MNI成人大脑模板可能对功能磁共振成像结果的影响不大。结论本研究为首发EOS患者DMN功能异常提供了依据。这些异常可能是异常内省导向的精神活动的来源。
Background The default mode network (DMN) has been linked to a number of mental disorders including schizophrenia. However, the abnormal connectivity of DMN in early onset schizophrenia (EOS) has been rarely reported. Methods Independent component analysis (ICA) was used to investigate functional connectivity (FC) of the DMN in 32 first-episode adolescents with EOS and 32 age and gender-matched healthy controls. Results Compared to healthy controls, patients with EOS showed increased FC between the medial frontal gyrus and other areas of the DMN. Partial correlation analyses showed that the FC of medial frontal gyrus significantly correlated with PANSS-positive symptoms (partial correlation coefficient = 0.538, Bonferoni corrected P = 0.018). Limitations Although the sample size of participants was comparable with most fMRI studies to date, it was still relatively small. Pediatric brains were registered to the MNI adult brain template. However, possible age-specific differences in spatial normalization that arise from registering pediatric brains to the MNI adult brain template may have little effect on fMRI results. Conclusion This study provides evidence for functional abnormalities of DMN in first-episode EOS. These abnormalities could be a source of abnormal introspectively-oriented mental actives.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Alexander-Bloch, Aaron;Lambiotte, Renaud;Roberts, Ben;Giedd, Jay;Gogtay, Nitin;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
5.7
作者：
FRISTON, KJ;HOLMES, AP;TURNER, R
通讯作者：
TURNER, R
影响因子：
4.5
作者：
Paillère-Martinot, ML;Caclin, A;Martinot, JL
通讯作者：
Martinot, JL
影响因子：
6.6
作者：
Bluhm, Robyn L.;Miller, Jodi;Williamson, Peter
通讯作者：
Williamson, Peter