Quantitative susceptibility mapping (QSM) of the cardiovascular system: challenges and perspectives.
Quantitative susceptibility mapping (QSM) of the cardiovascular system: challenges and perspectives.
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DOI：
10.1186/s12968-022-00883-z
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发表时间：
2022-08-18
影响因子：
6.4
通讯作者：
Masci, Pier-Giorgio
中科院分区：
文献类型：
--
作者：
Aimo, Alberto;Huang, Li;Tyler, Andrew;Barison, Andrea;Martini, Nicola;Saccaro, Luigi F.;Roujol, Sebastien;Masci, Pier-Giorgio
定量磁化率制图（QSM）是一种强大的、非侵入性的磁共振成像（MRI）技术，它依赖于磁化率的测量。到目前为止，QSM主要用于研究以铁积累为特征的神经系统疾病，如帕金森病和阿尔茨海默病。尽管如此，QSM允许绘制心脏疾病的关键指标，如血液氧合和心肌铁含量。因此，QSM的应用提供了一个前所未有的机会，可以更好地了解与心血管疾病相关的病理生理变化，并监测其演变和对治疗的反应。最近关于心血管QSM的研究表明，无创评估血氧、心肌铁含量、心肌纤维取向以及颈动脉斑块组成是可行的。重大的技术挑战仍然存在，其中最明显的是与心脏和呼吸运动、血流、化学位移效应和敏感性伪影有关。为了克服这些挑战并将QSM技术整合到心血管领域的临床实践中，正在进行重要的工作。
Quantitative susceptibility mapping (QSM) is a powerful, non-invasive, magnetic resonance imaging (MRI) technique that relies on measurement of magnetic susceptibility. So far, QSM has been employed mostly to study neurological disorders characterized by iron accumulation, such as Parkinson’s and Alzheimer’s diseases. Nonetheless, QSM allows mapping key indicators of cardiac disease such as blood oxygenation and myocardial iron content. For this reason, the application of QSM offers an unprecedented opportunity to gain a better understanding of the pathophysiological changes associated with cardiovascular disease and to monitor their evolution and response to treatment. Recent studies on cardiovascular QSM have shown the feasibility of a non-invasive assessment of blood oxygenation, myocardial iron content and myocardial fibre orientation, as well as carotid plaque composition. Significant technical challenges remain, the most evident of which are related to cardiac and respiratory motion, blood flow, chemical shift effects and susceptibility artefacts. Significant work is ongoing to overcome these challenges and integrate the QSM technique into clinical practice in the cardiovascular field.
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影响因子：
3.7
作者：
Bagnato F;Hametner S;Boyd E;Endmayr V;Shi Y;Ikonomidou V;Chen G;Pawate S;Lassmann H;Smith S;Welch EB
通讯作者：
Welch EB
DOI：
10.1186/s12968-016-0280-z
发表时间：
2016-09-22
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Captur G;Gatehouse P;Keenan KE;Heslinga FG;Bruehl R;Prothmann M;Graves MJ;Eames RJ;Torlasco C;Benedetti G;Donovan J;Ittermann B;Boubertakh R;Bathgate A;Royet C;Pang W;Nezafat R;Salerno M;Kellman P;Moon JC
通讯作者：
Moon JC
影响因子：
8.3
作者：
Altaf, Nishath;MacSweeney, Shane T.;Auer, Dorothee P.
通讯作者：
Auer, Dorothee P.
影响因子：
3.3
作者：
Bechler, Eric;Stabinska, Julia;Wittsack, Hans-Joerg
通讯作者：
Wittsack, Hans-Joerg
影响因子：
3.3
作者：
Henningsson, Markus;Smink, Jouke;Botnar, Rene M.
通讯作者：
Botnar, Rene M.