B chromosomes reveal a female meiotic drive suppression system in Drosophila melanogaster.
B chromosomes reveal a female meiotic drive suppression system in Drosophila melanogaster.
复制标题
DOI：
10.1016/j.cub.2023.04.028
复制
发表时间：
2023-06-05
期刊：
影响因子：
9.2
通讯作者：
Hawley, R. Scott
中科院分区：
文献类型：
--
作者：
Hanlon, Stacey L.;Hawley, R. Scott
自私的遗传元素使用多种机制来驱动它们的遗传并确保它们生存到下一代，这通常会损害宿主的健康。尽管自私遗传因素的目录正在迅速增长，但我们对抵消自私行为的宿主驱动力抑制系统的理解仍然缺乏。在这里，我们证明了果蝇中非必需、非驱动 B 染色体的偏向传递可以在特定的遗传背景下实现。将婚姻的无效突变体（一种编码 Polo 激酶女性特异性减数分裂调节因子的基因）与 TM3 平衡染色体相结合，创建了一种允许 B 染色体偏向传递的驱动基因型。这种驱动力是女性特有的，两种遗传成分都是必要的，但单独而言不足以实现 B 染色体的强大驱动力。对中期 I 卵母细胞的检查表明，当驱动力最强时，B 染色体在 DNA 团内的定位大部分是异常的，表明负责 B 染色体正确分布的机制出现故障。我们提出，一些对减数分裂期间染色体正确分离很重要的蛋白质，如婚姻，可能作为减数分裂驱动抑制系统的一部分发挥重要作用，该系统调节染色体分离，以防止遗传元件利用雌性减数分裂固有的不对称性。 B 染色体是遗传叛徒，如果不加以控制，可以在群体中迅速传播。 Hanlon 和 Hawley 表明，黑腹果蝇的 B 染色体在特定突变体中受到雌性减数分裂驱动，从而识别出一种驱动抑制系统，该系统可以防止自私遗传元件的入侵。
Selfish genetic elements use a myriad of mechanisms to drive their inheritance and ensure their survival into the next generation, often at a fitness cost to its host. Although the catalog of selfish genetic elements is rapidly growing, our understanding of host drive suppression systems that counteract self-seeking behavior is lacking. Here, we demonstrate that the biased transmission of the non-essential, non-driving B chromosomes in Drosophila melanogaster can be achieved in a specific genetic background. Combining a null mutant of matrimony, a gene that encodes a female-specific meiotic regulator of Polo kinase, with the TM3 balancer chromosome creates a driving genotype that is permissive for the biased transmission of the B chromosomes. This drive is female-specific, and both genetic components are necessary, but not individually sufficient, for permitting a strong drive of the B chromosomes. Examination of metaphase I oocytes reveals that B chromosome localization within the DNA mass is mostly abnormal when drive is the strongest, indicating a failure of the mechanism(s) responsible for the proper distribution of B chromosomes. We propose that some proteins important for proper chromosome segregation during meiosis, like Matrimony, may have an essential role as part of a meiotic drive suppression system that modulates chromosome segregation to prevent genetic elements from exploiting the inherent asymmetry of female meiosis. B chromosomes are genetic renegades that can rapidly spread through a population when left unchecked. Hanlon and Hawley show that the B chromosomes in D. melanogaster are subject to female meiotic drive in a specific mutant, leading to the identification of a drive suppression system that may protect against invasion by selfish genetic elements.
登录
查看更多内容
影响因子：
7.7
作者：
Habig, Michael;Kema, Gert H. J.;Stukenbrock, Eva Holtgrewe
通讯作者：
Stukenbrock, Eva Holtgrewe
影响因子：
1.6
作者：
HEWITT, GM
通讯作者：
HEWITT, GM
影响因子：
4.5
作者：
Hughes, Stacie E.;Gilliland, William D.;Hawley, R. Scott
通讯作者：
Hawley, R. Scott
影响因子：
64.5
作者：
Dawe, R. Kelly;Lowry, Elizabeth G.;Hiatt, Evelyn N.
通讯作者：
Hiatt, Evelyn N.
DOI：
10.1083/jcb.137.6.1321
发表时间：
1997-06-16
期刊：
The Journal of cell biology
影响因子：
--
作者：
Endow SA;Komma DJ
通讯作者：
Komma DJ