The Influence of Obesity and Associated Fatty Acids on Placental Inflammation.
The Influence of Obesity and Associated Fatty Acids on Placental Inflammation.
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肥胖及相关脂肪酸对胎盘炎症的影响。
DOI：
10.1016/j.clinthera.2020.12.018
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发表时间：
2021-03
影响因子：
3.2
通讯作者：
Aronoff DM
中科院分区：
文献类型：
--
作者：
Eastman AJ;Moore RE;Townsend SD;Gaddy JA;Aronoff DM
影响近四分之一妊娠的母亲肥胖与循环饱和脂肪酸（例如棕榈酸）增加有关。这些脂肪酸与胎盘炎症有关，进而可能加剧母胎耐受性和对 B 族链球菌等病原体的反应。在这篇综述中，我们解决了“肥胖和相关脂肪酸如何影响胎盘炎症？”的问题。在这篇叙述性综述中，我们使用了 PubMed 和 Google Scholar 的查询，使用了“胎盘炎症”或“妊娠”与“脂质”、“脂肪酸”、“肥胖”、“棕榈酸酯”或其他密切相关的搜索词的组合。我们还使用了在这些论文中找到的参考文献，这些参考文献可能在我们最初的搜索查询中不存在。我们分析了这些论文的方法和主要结果，以比较和对比他们的发现，这些发现有时彼此不一致。虽然肥胖可以作为一个整体进行研究，但体内小鼠模型和来自肥胖患者的人类样本的复杂现象通常依赖于用一种或多种脂肪酸以及偶尔其他化合物（例如葡萄糖和胰岛素）对细胞或组织的处理。我们发现，棕榈酸酯在体外最常用于重现肥胖特征，可诱导多种胎盘细胞类型的细胞凋亡、氧化应激、线粒体功能障碍、自噬缺陷和炎症小体激活。我们尽可能将其与体内肥胖模型进行比较。我们发现，与脂肪酸治疗（主要是棕榈酸盐）的体外模型相比，肥胖作为一个整体可能对这些现象（细胞凋亡、氧化应激、线粒体功能障碍、自噬缺陷和炎症小体激活）有更复杂的调节，因为不饱和脂肪酸（即油酸盐）的存在可能具有抗炎作用。不饱和脂肪酸与饱和脂肪酸的相互作用可能会单独改善饱和脂肪酸的许多炎症效应，这使得针对单独的特定脂肪酸的体外研究的解释变得复杂。这可以解释为什么某些体内肥胖研究显示出与体外特定脂肪酸研究不同的结果。
Maternal obesity, affecting nearly 1 in 4 pregnancies, is associated with increased circulating saturated fatty acids, such as palmitate. These fatty acids are implicated in placental inflammation, which may in turn exacerbate both maternal-fetal tolerance and responses to pathogens like Group B Streptococcus. In this review, we address the question “how do obesity and associated fatty acids influence placental inflammation?” In this narrative review, we used queries of PubMed and Google Scholar using combinations of “placental inflammation” or “pregnancy” and “lipids”, “fatty acids”, “obesity”, “palmitate” or other closely related search terms. We also used references found within these papers that may have been absent from our original search queries. We analyzed methods and key results of these papers to compare and contrast their findings, which were occasionally at odds with each other. While obesity can be studied as a whole, complex phenomena with in vivo mouse models and human samples from patients with obesity, in vitro modeling often relies on the treatment of cells or tissues with one or more fatty acids and occasionally other compounds (e.g. glucose and insulin). We have found that palmitate, most commonly used in vitro to recreate hallmarks of obesity, induces apoptosis, oxidative stress, mitochondrial dysfunction, autophagy defects, and inflammasome activation in many placental cell types. We compare this to in vivo models of obesity wherever possible. We find that obesity as a whole may have more complex regulation of these phenomena (apoptosis, oxidative stress, mitochondrial dysfunction, autophagy defects, and inflammasome activation) compared to in vitro models of fatty acid treatment (primarily palmitate) due to the presence of unsaturated fatty acids (i.e. oleate) which may have anti-inflammatory effects. The interaction of unsaturated fatty acids with saturated fatty acids may ameliorate many inflammatory effects of saturated fatty acids alone, which complicates interpretation of in vitro studies focusing on a particular fatty acid in isolation. This may explain why certain studies of obesity in vivo show differing outcomes from studies of specific fatty acids in vitro.
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影响因子：
1.6
作者：
Cohen, Matthew;Guo, Emily;Eastabrook, Genevieve
通讯作者：
Eastabrook, Genevieve
影响因子：
3.8
作者：
Alvarado, Fernanda L.;Calabuig-Navarro, Virtu;O'Tierney-Ginn, Perrie
通讯作者：
O'Tierney-Ginn, Perrie
影响因子：
3.8
作者：
Colvin, Bryanne N.;Longtine, Mark S.;Nelson, D. Michael
通讯作者：
Nelson, D. Michael
DOI：
10.1016/j.ajogmf.2020.100118
发表时间：
2020-05-01
影响因子：
6.3
作者：
Breslin, Noelle;Baptiste, Caitlin;Goffman, Dena
通讯作者：
Goffman, Dena
影响因子：
16
作者：
Cerritelli, SM;Frolova, EG;Crouch, RJ
通讯作者：
Crouch, RJ