Ventricular sensory endings mediate reflex bradycardia during coronary arteriography in humans.
Ventricular sensory endings mediate reflex bradycardia during coronary arteriography in humans.
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在人类冠状动脉造影期间，心室感觉末梢介导反射性心动过缓。
DOI：
10.1161/01.cir.80.5.1293
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发表时间：
1989
期刊：
影响因子：
37.8
通讯作者：
Thames,MD
中科院分区：
文献类型：
--
作者：
Arrowood,JA;Mohanty,PK;Hodgson,JM;Dibner-Dunlap,ME;Thames,MD
有人认为，冠状动脉内注射造影剂的反应是反射性的，是刺激心室感觉末梢的结果。心脏移植导致去神经的脑室，因此，可能中断这种反射的传入肢体。相反，受体的窦房结和残心仍然受到神经支配，使该反射的传出心脏完好无损。我们假设，如果造影剂诱导的反射性心动过缓和低血压是由于刺激心室化学敏感终末而发生的，那么这种反应在心脏移植后将被取消。为了验证这一假设，我们在心脏移植患者和心脏神经支配完整的患者的动脉造影术中，测定了选择性右冠状动脉(RCA)和左冠状动脉(LCA)注射期间受体(神经支配)和供体(去神经)窦结率(SNR)和平均动脉压的变化。在左冠状动脉和右冠状动脉注射期间，心脏移植患者的受体信噪比(LCA，6.6+/-1.7次/分钟；RCA，2.4+/-1.4次/分钟)高于对照组(LCA，-15.3+/-2.3次/分钟；RCA，-6.9+/-1.9次/分钟；与对照组相比，P<0.05)。尽管心脏移植患者的平均动脉压(LCA，-12.7+/-2.3 mm Hg；RCA，-11.4+/-2.2 mm Hg)和对照组的平均动脉压(LCA，-18.7+/-1.7 mm Hg；RCA，-10.7+/-1.6 mm Hg)显著和类似地下降，但仍发生了这种情况。注射LCA(-5.4+/-2.1次/分钟，p<0.05)和RCA(-3.0+/-1.7次/分钟)的供体信噪比减慢，而LCA的SNR减慢(p<0.05)。
It has been suggested that the response to the intracoronary injection of radiographic contrast is reflex in origin and results from stimulation of ventricular sensory endings. Cardiac transplantation results in denervation of the ventricles, and thus, may interrupt the afferent limb of this reflex. In contrast, the recipient sinus node and atrial remnant remain innervated, leaving the efferent cardiac limb of this reflex intact. We hypothesized that if contrast-induced reflex bradycardia and hypotension occurred from stimulation of ventricular chemosensitive endings, then this response would be abolished after cardiac transplantation. To test this hypothesis, we determined the changes in recipient (innervated) and donor (denervated) sinus-node rates (SNR) and mean arterial pressure during selective right (RCA) and left coronary artery (LCA) injection during arteriography in cardiac transplant patients and in patients with intact cardiac innervation. An increase in the recipient SNR was observed in cardiac transplant patients during left and right coronary injections (LCA, 6.6 +/- 1.7 beats/min; RCA, 2.4 +/- 1.4 beats/min) compared with a decrease in the control subjects (LCA, -15.3 +/- 2.3 beats/min; RCA, -6.9 +/- 1.9 beats/min; p less than 0.05 vs. control). This occurred despite significant and comparable decreases in mean arterial pressure in cardiac transplant patients (LCA, -12.7 +/- 2.3 mm Hg; RCA, -11.4 +/- 2.2 mm Hg) and control subjects (LCA, -18.7 +/- 1.7 mm Hg; RCA, -10.7 +/- 1.6 mm Hg). The donor SNR slowed for LCA injection (-5.4 +/- 2.1 beats/min, p less than 0.05) and RCA injection (-3.0 +/- 1.7 beats/min), which, for the LCA, was less than the slowing of control subjects (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
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狗的心脏受体，特别是心室壁中的两种类型的传入末梢
DOI：
--
发表时间：
1964
期刊：
Journal of Physiology
影响因子：
--
作者：
H. Coleridge;J. Coleridge;C. Kidd
通讯作者：
C. Kidd
狗冠状窦闭塞刺激心室机械感受器的动作电位
DOI：
10.1113/jphysiol.1972.sp009752
发表时间：
1972
期刊：
The Journal of Physiology
影响因子：
--
作者：
M. Muers;P. Sleight
通讯作者：
P. Sleight
抑制性心脏受体优先分布在狗的左心室。
影响因子：
--
作者：
J. L. Walker;M. Thames;F. Abboud;A. Mark;H. Klopfenstein
通讯作者：
H. Klopfenstein
冠状动脉造影引起的心室反射的起源。
影响因子：
--
作者：
F. Pérez;A. García
通讯作者：
A. García
猫非髓性迷走神经传入左心室受体的特征
影响因子：
20.1
作者：
P. Thoren
通讯作者：
P. Thoren