Gray and white matter structures in the midcingulate cortex region contribute to body mass index in Chinese young adults.
Gray and white matter structures in the midcingulate cortex region contribute to body mass index in Chinese young adults.
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中扣带皮层区域的灰质和白质结构有助于中国年轻人的体重指数
DOI：
10.1007/s00429-013-0657-9
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发表时间：
2015-01
影响因子：
3.1
通讯作者：
Bechara, Antoine
中科院分区：
文献类型：
--
作者：
He, Qinghua;Chen, Chuansheng;Dong, Qi;Xue, Gui;Chen, Chunhui;Lu, Zhong-Lin;Bechara, Antoine
关键词：
超重和肥胖正在迅速成为世界各地的一个主要公共卫生挑战。以前的研究表明，身体质量指数（BMI）升高可能与灰质和白色物质的结构变化有关，但这种联系仍然没有得到很好的理解。本研究的目的是在一个较小的年龄范围（20 ± 1岁）内，以相对较大的样本（N= 336）调查BMI与脑结构的关系。基于体素的形态测量结果显示，BMI和中扣带回皮质（MCC），左眶额叶皮质，左腹内侧前额叶皮质的灰质体积之间存在显着的负相关性。双侧扣带回各向异性分数与白色质完整性呈显著负相关。纤维束成像分析显示BMI与通过MCC区的纤维数量呈显著负相关。回归分析表明，这些区域的灰质和白色质都对BMI的方差有贡献。即使分析仅限于体重正常的受试者，这些结果仍具有显著性。最后，我们发现决策能力（由爱荷华州赌博任务评估）介导了MCC（负责冲动控制和决策的区域）结构与BMI之间的关联。这些结果揭示了体重变化的结构神经基础。
Overweight and obesity are rapidly becoming a central public health challenge around the world. Previous studies have suggested that elevated Body Mass Index (BMI) might be associated with structural changes in both gray and white matter, but this association is still not well understood. The present study aimed to investigate the relationship between BMI and brain structure with a relatively large sample of young adults (N= 336) in a small age range (20 ± 1 years). Voxel-based morphometry results showed significant negative correlations between BMI and gray-matter volumes in the midcingulate cortex (MCC), left orbital frontal cortex, and left ventromedial prefrontal cortex. There was also a significant negative correlation between BMI and white matter integrity as indexed by fractional anisotropy in bilateral cingulum. Further tractography analysis showed a significant negative correlation between BMI and the number of fibers passing the MCC region. Regression analysis showed that gray matter and white matter in these regions both contributed to the variance of BMI. These results remained significant even when analysis was restricted to the subjects with normal weights. Finally, we found that decision-making ability (as assessed by the Iowa Gambling Task) mediated the association between the structure of the MCC (a region responsible for impulse control and decision making) and BMI. These results shed light on the structural neural basis of weight variations.
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影响因子：
1.1
作者：
Bechara, A;Damasio, AR
通讯作者：
Damasio, AR
影响因子：
15.9
作者：
Cole MW;Yeung N;Freiwald WA;Botvinick M
通讯作者：
Botvinick M
DOI：
10.1017/s1355617710000354
发表时间：
2010-07-01
影响因子：
2.6
作者：
Brogan, Amy;Hevey, David;Pignatti, Riccardo
通讯作者：
Pignatti, Riccardo
影响因子：
5
作者：
Edwards, Todd L.;Edwards, Digna R. Velez;Matthews, Charles E.
通讯作者：
Matthews, Charles E.
影响因子：
11.3
作者：
Brevers, Damien;Cleeremans, Axel;Noel, Xavier
通讯作者：
Noel, Xavier