The Use of the Velocity Selective Recording Technique to Reveal the Excitation Properties of the Ulnar Nerve in Pigs.
The Use of the Velocity Selective Recording Technique to Reveal the Excitation Properties of the Ulnar Nerve in Pigs.
复制标题
DOI：
10.3390/s22010058
复制
发表时间：
2021-12-23
期刊：
影响因子：
--
通讯作者：
Dos Santos Nielsen TGN
中科院分区：
文献类型：
--
作者：
Andreis FR;Metcalfe B;Janjua TAM;Jensen W;Meijs S;Dos Santos Nielsen TGN
通过植入式神经接口解码来自周围神经系统的信息仍然是一个重大挑战，极大地限制了神经调节和神经假体设备的进步。速度选择性记录（VSR）技术已被提出，通过多电极袖带（MEC）结合时间和空间信息来改善神经交通的分类。因此，本研究探讨了使用 VSR 技术基于沿猪体内沿尺神经传播的电诱发复合动作电位 (eCAP) 来表征纤维类型的可行性。对九头丹麦地方品种猪的尺神经的皮肤和运动分支施加一系列电刺激参数（50 μA-10 mA 的幅度和 100 μs、500 μs、1000 μs 和 5000 μs 的脉冲持续时间）。使用 14 环 MEC 进行记录，并使用延迟相加算法将 eCAP 转换到速度域。结果显示，沿尺神经皮支传播的纤维群有两种，平均速度分别为 55 m/s 和 21 m/s，而运动支仅发现一种主要纤维群，平均速度为 63 m/s。由于 VSR 可以简单地提供有关神经纤维的纤维选择性和传播方向的信息，因此可以实现 VSR 来提高神经假体和生物电子医学应用的双向控制的性能。
Decoding information from the peripheral nervous system via implantable neural interfaces remains a significant challenge, considerably limiting the advancement of neuromodulation and neuroprosthetic devices. The velocity selective recording (VSR) technique has been proposed to improve the classification of neural traffic by combining temporal and spatial information through a multi-electrode cuff (MEC). Therefore, this study investigates the feasibility of using the VSR technique to characterise fibre type based on the electrically evoked compound action potentials (eCAP) propagating along the ulnar nerve of pigs in vivo. A range of electrical stimulation parameters (amplitudes of 50 μA–10 mA and pulse durations of 100 μs, 500 μs, 1000 μs, and 5000 μs) was applied on a cutaneous and a motor branch of the ulnar nerve in nine Danish landrace pigs. Recordings were made with a 14 ring MEC and a delay-and-add algorithm was used to convert the eCAPs into the velocity domain. The results revealed two fibre populations propagating along the cutaneous branch of the ulnar nerve, with mean velocities of 55 m/s and 21 m/s, while only one dominant fibre population was found for the motor branch, with a mean velocity of 63 m/s. Because of its simplicity to provide information on the fibre selectivity and direction of propagation of nerve fibres, VSR can be implemented to advance the performance of the bidirectional control of neural prostheses and bioelectronic medicine applications.
登录
查看更多内容
影响因子：
4
作者：
Anh Tuan Nguyen;Xu, Jian;Yang, Zhi
通讯作者：
Yang, Zhi
影响因子：
2.5
作者：
Ackerley, Rochelle;Wasling, Helena Backlund;Wessberg, Johan
通讯作者：
Wessberg, Johan
影响因子：
3.8
作者：
Galtrey, Clare M.;Fawcett, James W.
通讯作者：
Fawcett, James W.
影响因子：
2.6
作者：
Elliott, Robert E.;Morsi, Amr;Doyle, Werner K.
通讯作者：
Doyle, Werner K.
影响因子：
3.2
作者：
Donaldson, N.;Rieger, R.;Taylor, J.
通讯作者：
Taylor, J.