Telomere length and genetic analyses in population-based studies of endometrial cancer risk.
Telomere length and genetic analyses in population-based studies of endometrial cancer risk.
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DOI：
10.1002/cncr.25328
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发表时间：
2010-09-15
期刊：
影响因子：
6.2
通讯作者：
De Vivo, Immaculata
中科院分区：
文献类型：
--
作者：
Prescott, Jennifer;McGrath, Monica;Lee, I-Min;Buring, Julie E.;De Vivo, Immaculata
端粒是位于线性染色体末端的保护性结构，由许多相关蛋白调节。当端粒功能失调时，基因组的不稳定性就会随之而来。绝大多数细胞经历凋亡，尽管少数细胞可以存活并成为致瘤细胞。我们使用条件Logistic回归分析外周血白细胞中的相对端粒长度、端粒维持基因位点的遗传变异（TERT、TNKS 2、POT 1、TERF 1、TERF 2）以及护士健康研究和妇女健康研究中嵌套的病例对照研究中的子宫内膜癌风险。相对端粒长度与18岁以后的BMI和体重增加呈显著负相关。我们没有观察到端粒相对长度与子宫内膜癌风险之间的关系。与最长四分位数的女性相比，最短四分位数的女性的多变量调整优势比（OR）= 1.20（95%置信区间（CI）= 0.73 - 1.96，Ptrend = 0.37）。我们发现携带至少一个rs 2736122（TERT; OR = 1.18，95%CI = 1.01 - 1.38）或RS 12412538（TNKS 2; OR = 1.16，95%CI = 1.00 - 1.34）次要等位基因的妇女子宫内膜癌风险升高。端粒相对长度与子宫内膜癌风险无关。端粒维持的其他方面仍有待探索。
Telomeres are protective structures at the ends of linear chromosomes, regulated by a host of associated proteins. When telomeres become dysfunctional genomic instability ensues. The vast majority of cells undergo apoptosis, though a rare cell may survive and become tumorigenic. We used conditional logistic regression to examine relative telomere length in peripheral blood leukocytes, genetic variants at telomere maintenance gene loci (TERT, TNKS2, POT1, TERF1, TERF2), and endometrial cancer risk in case-control studies nested within the Nurses’ Health Study and the Women's Health Study. Relative telomere length was significantly inversely correlated with BMI and weight gain since age 18. We did not observe a relationship between relative telomere length and endometrial cancer risk. Women in the shortest quartile had a multivariate-adjusted odds ratio (OR) = 1.20 (95% confidence interval (CI) = 0.73 – 1.96, Ptrend = 0.37) compared with women in the longest quartile. We found an elevation in endometrial cancer risk among women carrying at least one minor allele of rs2736122 (TERT; OR = 1.18, 95% CI = 1.01 – 1.38) or RS12412538 (TNKS2; OR = 1.16, 95% CI = 1.00 – 1.34). Relative telomere length was not associated with endometrial cancer risk. Other aspects of telomere maintenance remain to be explored.
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影响因子：
4.5
作者：
Nordfjall, Katarina;Svenson, Ulrika;Norrback, Karl-Fredrik;Adolfsson, Rolf;Lenner, Per;Roos, Goran
通讯作者：
Roos, Goran
DOI：
10.1158/1055-9965.epi-08-0935
发表时间：
2009-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kim S;Parks CG;DeRoo LA;Chen H;Taylor JA;Cawthon RM;Sandler DP
通讯作者：
Sandler DP
影响因子：
5.8
作者：
Bau, A. M.;Ernert, A.;Krude, H.
通讯作者：
Krude, H.
影响因子：
3.3
作者：
Bonatz, G;Frahm, SO;Rudolph, P
通讯作者：
Rudolph, P
影响因子：
3.8
作者：
McGrath, Monica;Wong, Jason Y. Y.;De Vivo, Immaculata
通讯作者：
De Vivo, Immaculata