A Gonococcal Vaccine Has the Potential to Rapidly Reduce the Incidence of Neisseria gonorrhoeae Infection Among Urban Men Who Have Sex With Men.
A Gonococcal Vaccine Has the Potential to Rapidly Reduce the Incidence of Neisseria gonorrhoeae Infection Among Urban Men Who Have Sex With Men.
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淋球菌疫苗有可能快速降低与男性发生性关系的城市男性中淋病感染的发生率。
DOI：
10.1093/infdis/jiab581
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发表时间：
2022-03-15
期刊：
影响因子：
--
通讯作者：
Seib KL
中科院分区：
文献类型：
--
作者：
Hui BB;Padeniya TN;Rebuli N;Gray RT;Wood JG;Donovan B;Duan Q;Guy R;Hocking JS;Lahra MM;Lewis DA;Whiley DM;Regan DG;Seib KL
由于淋病发病率的增加和世界范围内出现的多重耐药淋球菌菌株，迫切需要淋球菌疫苗。男男性行为者（MSM）是淋病发病率最高的人群之一，可能是疫苗接种的关键目标人群。一个基于个体的，解剖部位特异性的数学模型被用来模拟淋病奈瑟菌在10 000 MSM人群中的传播。 评估了接种疫苗对淋病流行率的影响。在100%或50%保护效力的淋球菌疫苗的情况下，如果30%的MSM在性传播感染（STI）检测时接种疫苗，淋病患病率可以在2年内分别降低94%或62%。如果平均每3年进行一次加强疫苗接种，则淋病有可能在8年内消除，疫苗的有效性≥50%，持续2年。 如果疫苗不是在所有解剖部位都有效，那么它的影响可能会减少。我们的研究表明，通过适度有效的疫苗和针对MSM进行STI筛查的免疫策略，该人群中淋病的患病率可以迅速大幅降低。模型被用来评估淋病奈瑟菌疫苗在MSM中的潜在影响。效力中等的疫苗可以大大降低流行率，但如果疫苗对预防口咽感染无效，则疫苗接种的影响会降低。
A gonococcal vaccine is urgently needed due to increasing gonorrhea incidence and emerging multidrug-resistant gonococcal strains worldwide. Men who have sex with men (MSM) have among the highest incidences of gonorrhea and may be a key target population for vaccination when available. An individual-based, anatomical site-specific mathematical model was used to simulate Neisseria gonorrhoeae transmission in a population of 10 000 MSM. The impact of vaccination on gonorrhea prevalence was assessed. With a gonococcal vaccine of 100% or 50% protective efficacy, gonorrhea prevalence could be reduced by 94% or 62%, respectively, within 2 years if 30% of MSM are vaccinated on presentation for sexually transmitted infection (STI) testing. Elimination of gonorrhea is possible within 8 years with vaccines of ≥ 50% efficacy lasting 2 years, providing a booster vaccination is available every 3 years on average. A vaccine’s impact may be reduced if it is not effective at all anatomical sites. Our study indicates that with a vaccine of modest efficacy and an immunization strategy that targets MSM presenting for STI screening, the prevalence of gonorrhea in this population could be rapidly and substantially reduced. Modelling was used to assess the potential impact of a Neisseria gonorrhoeaevaccine among MSM. A vaccine of modest efficacy could reduce prevalence substantially, but the impact of vaccination is reduced if the vaccine is ineffective at preventing oropharyngeal infection.
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影响因子：
4.4
作者：
Gafos M;Horne R;Nutland W;Bell G;Rae C;Wayal S;Rayment M;Clarke A;Schembri G;Gilson R;McOwan A;Sullivan A;Fox J;Apea V;Dewsnap C;Dolling D;White E;Brodnicki E;Wood G;Dunn D;McCormack S
通讯作者：
McCormack S
影响因子：
5.5
作者：
Gottlieb SL;Deal CD;Giersing B;Rees H;Bolan G;Johnston C;Timms P;Gray-Owen SD;Jerse AE;Cameron CE;Moorthy VS;Kiarie J;Broutet N
通讯作者：
Broutet N
影响因子：
3.6
作者：
Chow, Eric P. F.;Lee, David;Fairley, Christopher K.
通讯作者：
Fairley, Christopher K.
影响因子：
11.8
作者：
Bernstein, Kyle T.;Stephens, Sally C.;Klausner, Jeffrey D.
通讯作者：
Klausner, Jeffrey D.
影响因子：
4.4
作者：
Crawford, June M.;Kippax, Susan C.;Kaldor, John
通讯作者：
Kaldor, John