Choroidal Structure in Children with Anisohypermetropic Amblyopia Determined by Binarization of Optical Coherence Tomographic Images.
Choroidal Structure in Children with Anisohypermetropic Amblyopia Determined by Binarization of Optical Coherence Tomographic Images.
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DOI：
10.1371/journal.pone.0164672
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Ogata N
中科院分区：
文献类型：
--
作者：
Nishi T;Ueda T;Mizusawa Y;Shinomiya K;Semba K;Mitamura Y;Sonoda S;Uchino E;Sakamoto T;Ogata N
通过对增强型深度成像光学相干断层扫描（EDI-OCT）获得的图像进行二值化，比较各向异性远视性弱视儿童与对侧眼和年龄匹配的对照眼中心凹下区域的脉络膜结构。本研究在日本奈良医科大学医院、德岛大学医院和鹿儿岛大学医院进行。研究对象为40只各向异性远视性弱视眼及其对侧眼（5.9 ± 2.1岁，平均值±标准差）和103只年龄匹配的对照眼（6.7 ± 2.4岁）。对照眼分为近视眼、正视眼和远视眼。用二值化法测量中心凹下脉络膜的总面积、腔面积和基质面积。将弱视眼的管腔/基质比和眼轴长度与对照眼进行比较。弱视眼脉络膜总面积明显大于对侧眼（P = 0.005）。弱视眼的管腔/基质比显著大于对侧眼（P<0.001）和对照远视眼（P<0.001）。对照眼眼轴长与管腔/基质比呈显著负相关（r =-0.30，P = 0.001），弱视眼相关性不显著。弱视眼的脉络膜结构与远视眼和对照眼不同。脉络膜改变与弱视有关。
To compare the choroidal structure of the subfoveal area in the eyes of children with anisohypermetropic amblyopia to that of the fellow eyes and to age-matched controls using a binarization method of the images obtained by enhanced depth imaging optical coherence tomography (EDI-OCT). This study was performed at Nara Medical University Hospital, Tokushima University Hospital, and Kagoshima University Hospital, Japan. Forty amblyopic eyes with anisohypermetropic amblyopia and their fellow eyes (5.9 ± 2.1 years, mean ± standard deviation), and 103 age-matched controls (6.7 ± 2.4 years) were studied. The control eyes were divided into myopic, emmetropic, and hyperopic eyes. The total choroidal area, luminal area and stromal area of the subfoveal choroid were measured by the binarization method. The luminal/stromal ratio and the axial length of the amblyopic eyes were compared to that of the control eyes. The total choroidal area in the amblyopic eyes was significantly larger than that of the fellow eyes (P = 0.005). The luminal/stromal ratio was significantly larger in the amblyopic eyes than that of the fellow eyes (P<0.001) and the control hyperopic eyes (P<0.001). There was a significant negative correlation between the luminal/stromal ratio and the axial length in the control eyes (r = -0.30, P = 0.001), but no significant correlation was found in the amblyopic eyes. The choroidal structure of the amblyopic eyes was different from that of the fellow and the control hyperopic eyes. The choroidal changes are related to amblyopia.
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影响因子：
13.7
作者：
Branchini LA;Adhi M;Regatieri CV;Nandakumar N;Liu JJ;Laver N;Fujimoto JG;Duker JS
通讯作者：
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4.4
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通讯作者：
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2.4
作者：
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通讯作者：
May, CA