Entorhinal cortex structure and functional MRI response during an associative verbal memory task.
Entorhinal cortex structure and functional MRI response during an associative verbal memory task.
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DOI：
10.1002/hbm.20823
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发表时间：
2009-12
影响因子：
4.8
通讯作者：
Bookheimer, Susan Y.
中科院分区：
文献类型：
--
作者：
Braskie, Meredith N.;Small, Gary W.;Bookheimer, Susan Y.
成人轻度认知障碍患者的内嗅皮层（ERC）体积已被证明可预测前驱阿尔茨海默病（AD）。同样，ERC的神经元缺失与AD有关，但与正常衰老无关。由于ERC是调节海马体输入的主要通路的一部分，其结构变化可能导致记忆任务期间认知表现和大脑功能活动的改变。在32名认知完好的老年人中，我们研究了在联想性言语记忆任务期间左侧ERC厚度与功能性磁共振成像（fMRI）活动之间的关系。此前已表明该任务可激活对衰老和AD风险敏感的区域。ERC是在原生空间、高分辨率、斜冠状MRI扫描上手动定义的。左侧ERC较厚的受试者在记忆提取（而非编码）过程中，在前扣带回和内侧额叶区域表现出更强的激活。这一结果与海马体积无关。前扣带回皮层与ERC直接相连，并且与内侧额叶皮层一起涉及错误检测，而错误检测在AD中受损。我们的研究结果表明，在健康的老年人中，记忆提取过程中涉及额叶区域的过程与ERC结构有关。
Entorhinal cortex (ERC) volume in adults with mild cognitive impairment has been shown to predict prodromal Alzheimer's disease (AD). Likewise, neuronal loss in ERC has been associated with AD, but not with normal aging. Because ERC is part of a major pathway modulating input to the hippocampus, structural changes there may result in changes to cognitive performance and functional brain activity during memory tasks. In 32 cognitively intact older adults, we examined the relationship between left ERC thickness and functional magnetic resonance imaging (fMRI) activity during an associative verbal memory task. This task has been shown previously to activate regions that are sensitive to aging and AD risk. ERC was manually defined on native space, high resolution, oblique coronal MRI scans. Subjects having thicker left ERC showed greater activation in anterior cingulate and medial frontal regions during memory retrieval, but not encoding. This result was independent of hippocampal volume. Anterior cingulate cortex is directly connected to ERC, and is, along with medial frontal cortex, implicated in error detection, which is impaired in AD. Our results suggest that in healthy older adults, processes that engage frontal regions during memory retrieval are related to ERC structure.
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