Maternal depressive symptoms, neonatal white matter, and toddler social-emotional development.
Maternal depressive symptoms, neonatal white matter, and toddler social-emotional development.
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DOI：
10.1038/s41398-022-02073-y
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发表时间：
2022-08-09
影响因子：
6.8
通讯作者：
Counsell, Serena J.
中科院分区：
文献类型：
--
作者：
Lautarescu, Alexandra;Bonthrone, Alexandra F.;Pietsch, Maximilian;Batalle, Dafnis;Cordero-Grande, Lucilio;Tournier, J-Donald;Christiaens, Daan;Hajnal, Joseph, V;Chew, Andrew;Falconer, Shona;Nosarti, Chiara;Victor, Suresh;Craig, Michael C.;Edwards, A. David;Counsell, Serena J.
母亲产前抑郁症与后代神经发育和精神疾病的可能性增加有关。母亲抑郁症和后代结果之间的关系可能是通过子宫内大脑发育的变化来介导的。磁共振成像（MRI）的最新进展使新生儿大脑的体内研究，最大限度地减少出生后的影响。本研究的目的是检查产妇产前抑郁症状，婴儿白色物质，和幼儿行为之间的关联。413对母婴参加了正在发展的人类连接组项目。母亲完成了爱丁堡产后抑郁量表（中位数= 5，范围= 0 - 28，n = 52分≥ 11）。婴儿（n = 223例男性）（出生时的中位胎龄= 40周，范围32.14 - 42.29）接受了MRI（扫描时的中位月经后年龄= 41.29周，范围36.57 - 44.71）。固定为基础的纤维指标（平均纤维密度，纤维横截面，和纤维密度调制的横截面）计算从扩散成像数据在左，右钩束和扣带束。对于n = 311，在18个月的中位校正年龄（范围17 - 24）时报告了内化和外化行为以及社交情感能力。统计分析采用多元线性回归和中介分析与自助法。母亲的抑郁症状与婴儿左侧的纤维密度呈正相关，（B = 0.0005，p = 0.003，q = 0.027）和右侧（B = 0.0006，p = 0.003，q = 0.027）钩束，左钩束纤维密度依次为，与幼儿期的社会情感能力呈正相关（B = 105.70，p = 0.0007，q = 0.004）。在一项中介分析中，较高的母亲抑郁症状预示着幼儿的社会情感困难（B = 0.342，t（307）= 3.003，p = 0.003），但这种关系不是由左钩束中的纤维密度介导的（Sobel检验p = 0.143，自助间接效应= 0.035，SE = 0.02，95% CI：[-0.01，0.08]）。没有证据表明母亲抑郁和扣带纤维属性之间的关联。这些研究结果表明，母亲围产期抑郁症状与新生儿钩束微结构，但不纤维束的大小，和幼儿的行为。
Maternal prenatal depression is associated with increased likelihood of neurodevelopmental and psychiatric conditions in offspring. The relationship between maternal depression and offspring outcome may be mediated by in-utero changes in brain development. Recent advances in magnetic resonance imaging (MRI) have enabled in vivo investigations of neonatal brains, minimising the effect of postnatal influences. The aim of this study was to examine associations between maternal prenatal depressive symptoms, infant white matter, and toddler behaviour. 413 mother-infant dyads enrolled in the developing Human Connectome Project. Mothers completed the Edinburgh Postnatal Depression Scale (median = 5, range = 0–28, n = 52 scores ≥ 11). Infants (n = 223 male) (median gestational age at birth = 40 weeks, range 32.14–42.29) underwent MRI (median postmenstrual age at scan = 41.29 weeks, range 36.57–44.71). Fixel-based fibre metrics (mean fibre density, fibre cross-section, and fibre density modulated by cross-section) were calculated from diffusion imaging data in the left and right uncinate fasciculi and cingulum bundle. For n = 311, internalising and externalising behaviour, and social-emotional abilities were reported at a median corrected age of 18 months (range 17–24). Statistical analysis used multiple linear regression and mediation analysis with bootstrapping. Maternal depressive symptoms were positively associated with infant fibre density in the left (B = 0.0005, p = 0.003, q = 0.027) and right (B = 0.0006, p = 0.003, q = 0.027) uncinate fasciculus, with left uncinate fasciculus fibre density, in turn, positively associated with social-emotional abilities in toddlerhood (B = 105.70, p = 0.0007, q = 0.004). In a mediation analysis, higher maternal depressive symptoms predicted toddler social-emotional difficulties (B = 0.342, t(307) = 3.003, p = 0.003), but this relationship was not mediated by fibre density in the left uncinate fasciculus (Sobel test p = 0.143, bootstrapped indirect effect = 0.035, SE = 0.02, 95% CI: [−0.01, 0.08]). There was no evidence of an association between maternal depressive and cingulum fibre properties. These findings suggest that maternal perinatal depressive symptoms are associated with neonatal uncinate fasciculi microstructure, but not fibre bundle size, and toddler behaviour.
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