Greater age-related changes in white matter morphometry following early life stress: Associations with internalizing problems in adolescence.
Greater age-related changes in white matter morphometry following early life stress: Associations with internalizing problems in adolescence.
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DOI：
10.1016/j.dcn.2020.100899
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发表时间：
2021-03
影响因子：
4.7
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Chahal R;Kirshenbaum JS;Ho TC;Mastrovito D;Gotlib IH
我们测试了早期生活压力（ELS）对年龄-白质（WM）关系的影响。高ELS青年表现出更大的年龄WM协会在几个大片。这些神经束将额叶与边缘、枕叶和顶叶连接起来。具有较高ELS的年长青年表现出负钩齿内化关联。更成熟的钩突形态测量可能是适应ELS暴露的青少年。早期生活压力（ELS）与内化障碍和灰质发育变化的风险增加有关。然而，目前尚不清楚ELS是否会影响白色物质（WM）形态的正常年龄相关变化，以及这种成熟差异是否与内化精神病理学的风险相关。我们在青少年（N = 156; 89 F;年龄9-14）的横断面样本中进行了全面的访谈，以评估终身暴露于压力和客观累积ELS严重程度。我们使用扩散加权成像来测量WM固定为基础的形态学，并测试了年龄和ELS对WM纤维密度和横截面（FDC）的影响，以及WM FDC和内化问题之间的关联。年龄与所有WM束中的FDC呈正相关;在连接额叶与边缘、顶叶和枕叶区域（包括双侧上级和下级纵束和钩束（UF））的几个关联束中，更大的ELS严重程度与更强的年龄-WM关联相关。在年龄较大的青少年与更大的ELS严重程度，较高的UF FDC与较少的内化问题。更大的ELS严重程度预测更成熟的WM形态测量学涉及情绪调节和认知处理的大片。更多的表型成熟的UF WM可能是适应对内在的精神病理学暴露于ELS的青少年。
We tested the impact of early life stress (ELS) on age-white matter (WM) relations. Higher ELS youth showed greater age-WM associations in several tracts. These tracts connected frontal regions with limbic, occipital, and parietal regions. Older youth with higher ELS showed a negative uncinate-internalizing association. More mature uncinate morphometry may be adaptive in ELS-exposed adolescents. Early life stress (ELS) is associated with increased risk for internalizing disorders and variations in gray matter development. It is unclear, however, whether ELS affects normative age-related changes in white matter (WM) morphology, and if such maturational differences are associated with risk for internalizing psychopathology. We conducted comprehensive interviews in a cross-sectional sample of young adolescents (N = 156; 89 F; Ages 9–14) to assess lifetime exposure to stress and objective cumulative ELS severity. We used diffusion-weighted imaging to measure WM fixel-based morphometry and tested the effects of age and ELS on WM fiber density and cross-section (FDC), and associations between WM FDC and internalizing problems. Age was positively associated with FDC in all WM tracts; greater ELS severity was related to stronger age-WM associations in several association tracts connecting the frontal lobes with limbic, parietal, and occipital regions, including bilateral superior and inferior longitudinal and uncinate fasciculi (UF). Among older adolescents with greater ELS severity, a higher UF FDC was associated with fewer internalizing problems. Greater ELS severity predicted more mature WM morphometry in tracts implicated in emotion regulation and cognitive processing. More phenotypically mature UF WM may be adaptive against internalizing psychopathology in adolescents exposed to ELS.
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