Observer's anxiety facilitates magnocellular processing of clear facial threat cues, but impairs parvocellular processing of ambiguous facial threat cues.
Observer's anxiety facilitates magnocellular processing of clear facial threat cues, but impairs parvocellular processing of ambiguous facial threat cues.
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DOI：
10.1038/s41598-017-15495-2
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发表时间：
2017-11-09
影响因子：
4.6
通讯作者：
Kveraga K
中科院分区：
文献类型：
--
作者：
Im HY;Adams RB Jr;Boshyan J;Ward N;Cushing CA;Kveraga K
面部表情和眼睛凝视提供了关于威胁的共同信号。虽然带有转移目光的恐惧表情清楚地指向威胁的来源，但直视恐惧使威胁的来源变得模糊。已经提出了可分离的途径来介导这些过程，其中大细胞（M）途径优先调谐以清除威胁，而小细胞（P）途径优先调谐以威胁模糊。在这里，我们研究了观察者的特质焦虑如何调节M-和P-通路处理明确和模糊的威胁线索。我们扫描的主题（N = 108）广泛的特质焦虑，而他们看到了恐惧或中性的面孔与回避或定向凝视，与亮度和颜色的面部刺激校准，选择性地从事M-或P-通路。较高的焦虑促进了对投射到M-通路的明确威胁的处理，但削弱了对投射到P-通路的模糊威胁的感知。右侧杏仁核反应性的增加与M偏置回避凝视恐惧的更高焦虑有关，而左侧杏仁核反应性的增加与P偏置直视恐惧的更高焦虑有关。这种偏侧化在焦虑程度越高时越明显。我们的研究结果表明，特质焦虑差异影响感知明确的（回避凝视恐惧）和模糊的（直接凝视恐惧）面部威胁线索，通过选择性参与的M和P通路和侧化杏仁核反应。
Facial expression and eye gaze provide a shared signal about threats. While a fear expression with averted gaze clearly points to the source of threat, direct-gaze fear renders the source of threat ambiguous. Separable routes have been proposed to mediate these processes, with preferential attunement of the magnocellular (M) pathway to clear threat, and of the parvocellular (P) pathway to threat ambiguity. Here we investigated how observers’ trait anxiety modulates M- and P-pathway processing of clear and ambiguous threat cues. We scanned subjects (N = 108) widely ranging in trait anxiety while they viewed fearful or neutral faces with averted or directed gaze, with the luminance and color of face stimuli calibrated to selectively engage M- or P-pathways. Higher anxiety facilitated processing of clear threat projected to M-pathway, but impaired perception of ambiguous threat projected to P-pathway. Increased right amygdala reactivity was associated with higher anxiety for M-biased averted-gaze fear, while increased left amygdala reactivity was associated with higher anxiety for P-biased, direct-gaze fear. This lateralization was more pronounced with higher anxiety. Our findings suggest that trait anxiety differentially affects perception of clear (averted-gaze fear) and ambiguous (direct-gaze fear) facial threat cues via selective engagement of M and P pathways and lateralized amygdala reactivity.
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影响因子：
25
作者：
Bishop, S;Duncan, J;Lawrence, AD
通讯作者：
Lawrence, AD
影响因子：
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作者：
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Kleck, RE
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通讯作者：
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通讯作者：
Benton, Christopher P.