Bone marrow-derived HipOP cell population is markedly enriched in osteoprogenitors.
Bone marrow-derived HipOP cell population is markedly enriched in osteoprogenitors.
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DOI：
10.3390/ijms130810229
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发表时间：
2012
影响因子：
5.6
通讯作者：
Aubin JE
中科院分区：
文献类型：
--
作者：
Itoh S;Matsushita K;Ikeda S;Yamamoto Y;Yamauchi Y;Yoshioka S;Yamamoto R;Ebisu S;Hayashi M;Aubin JE
We recently succeeded in purifying a novel multipotential progenitor or stem cell population from bone marrow stromal cells (BMSCs). This population exhibited a very high frequency of colony forming units-osteoblast (CFU-O; 100 times higher than in BMSCs) and high expression levels of osteoblast differentiation markers. Furthermore, large masses of mineralized tissue were observed in in vivo transplants with this new population, designated highly purified osteoprogenitors (HipOPs). We now report the detailed presence and localization of HipOPs and recipient cells in transplants, and demonstrate that there is a strong relationship between the mineralized tissue volume formed and the transplanted number of HipOPs.
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