Effects of electroacupuncture on anxiety and depression in unmarried patients with polycystic ovarian syndrome: secondary analysis of a pilot randomised controlled trial
Effects of electroacupuncture on anxiety and depression in unmarried patients with polycystic ovarian syndrome: secondary analysis of a pilot randomised controlled trial
复制标题
电针对未婚多囊卵巢综合征患者焦虑和抑郁的影响：一项试点随机对照试验的二次分析
DOI：
10.1136/acupmed-2017-011615
复制
发表时间：
2019-02
期刊：
影响因子：
--
通讯作者：
Huang D
中科院分区：
文献类型：
--
作者：
Wang Z;Dong H;Wang Q;Zhang L;Wu X;Zhou Z;Yang L;Huang D
目的：通过随机对照试验的二次分析，评价电针（EA）治疗未婚多囊卵巢综合征（PCOS）患者焦虑和抑郁的疗效。方法：2012年11月至2016年3月在未婚PCOS女性中进行了一项前瞻性随机对照试验。参与者被分配到针灸组（接受EA 16周）或对照组（接受假针灸16周），每组27例患者。将单独报告预先规定的主要结局和所有次要结局，包括去甲肾上腺素（NE）、肾上腺素（AD）、5-羟色胺（5-HT）和γ-氨基丁酸（GABA）在内的神经递质的血清水平除外。选择用于该次要分析的其他结局指标包括焦虑和抑郁量表评分（Zung-SAS和Zung-SDS）、36项简表（SF-36）量表评分、PCOS生活质量（PCOSQOL）量表评分和中国人生活质量（CHQOL）量表评分。结果如下：针刺组治疗16周后血清NE水平升高，5-HT水平降低（P=0.028和P=0.023）。干预后两组血清GABA水平均下降（均P<0.001）。两组间各递质水平无显著性差异（p>0.05）。电针治疗后，针刺组SAS、SDS评分降低（分别为P=0.007和P=0.027），低于对照组（分别为P=0.003和P=0.004）。SF-36的精神健康、活力、社会功能、一般健康和健康过渡领域得分、CHQOL总分、PCOSQOL的不孕问题和体毛领域得分在电针治疗后均显著改善（P<0.05）。结论：电针可改善PCOS患者的焦虑/抑郁症状和生活质量，并可能影响血清NE和5-HT水平。鉴于本文报告的结局指标的次要性质，应谨慎解释这些结果。试验注册号：NCT 01812161; ChiCTR-TRC-12002529
Objective: To evaluate the efficacy of electroacupuncture (EA) for the treatment of anxiety and depression in unmarried patients with polycystic ovarian syndrome (PCOS) by secondary analysis of a randomised controlled trial. Methods: A prospective pilot randomised controlled trial of unmarried women with PCOS was conducted from November 2012 to March 2016. Participants were assigned to the acupuncture group (receiving EA for 16 weeks) or the control group (receiving sham acupuncture for 16 weeks), with 27 patients in each group. The pre-specified primary outcomes and all secondary outcomes, with the exception of serum levels of neurotransmitters including norepinephrine (NE), epinephrine (AD), serotonin (5-HT) and γ-aminobutyric acid (GABA), will be reported separately. Additional outcome measures selected for this secondary analysis included anxiety and depression scale scores (Zung-SAS and Zung-SDS), 36-Item Short Form (SF-36) scale scores, PCOS Quality of Life (PCOSQOL) scale scores and Chinese Quality of Life (CHQOL) scale scores. Results: After the16-week intervention, an increase in serum NE and reduction in 5-HT were observed in the acupuncture group (P=0.028 and P=0.023, respectively). The serum level of GABA decreased in both groups after the interventions (both P<0.001). However, there were no significant differences between the two groups in the levels of any neurotransmitters (p>0.05). After EA treatment, SAS and SDS scores were decreased in the acupuncture group (P=0.007 and P=0.027, respectively) and were lower than those of the control group (P=0.003 and P=0.004, respectively). The SF-36 domain scores for mental health, vitality, social functioning, general health and health transition, the total CHQOL scores, and the infertility problems and body hair domains of the PCOSQOL improved significantly after EA (P<0.05). Conclusion: EA appears to improve symptoms of anxiety/depression and quality of life in PCOS patients and may influence serum levels of NE and 5-HT. These findings should be interpreted with caution, given the secondary nature of the outcome measures reported herein. Trial registration number: NCT01812161; ChiCTR-TRC-12002529
登录
查看更多内容
影响因子：
2.4
作者：
Prabhakar V;Gupta D;Kanade P;Radhakrishnan M
通讯作者：
Radhakrishnan M
影响因子：
6.6
作者：
Chung, Ka-Fai;Yeung, Wing-Fai;Wong, Vivian Taam
通讯作者：
Wong, Vivian Taam
影响因子：
6.1
作者：
Fauser, BCJM;Chang, J;Lobo, R
通讯作者：
Lobo, R
影响因子：
3.1
作者：
Kvorning, Nina;Akeson, Jonas
通讯作者：
Akeson, Jonas
影响因子：
6.1
作者：
Deeks, A. A.;Gibson-Helm, M. E.;Teede, H. J.
通讯作者：
Teede, H. J.