Surface Modification of Polymer Substrates for Biomedical Applications.

Surface Modification of Polymer Substrates for Biomedical Applications.
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DOI:
10.3390/ma10101115
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发表时间:
2017-09-21
期刊:
Materials (Basel, Switzerland)
影响因子:
--
通讯作者:
Švorčík V
Švorčík V
中科院分区:
其他
文献类型:
--
作者:
Neděla O;Slepička P;Švorčík V

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虽然聚合物是生物医学工业中广泛使用的材料,但它们很少以未改性状态使用。通常需要进行某种表面处理以获得适用于特定应用的性能。有多种表面处理方法,每种方法都有自己的优缺点,例如等离子体和激光处理,UV灯改性,蚀刻,接枝,金属化,离子溅射等。适当的处理可以改变聚合物表面的物理化学性质,使其对各种生物化合物具有吸引力,或者相反,使聚合物表现出抗菌或细胞毒性性质,从而使聚合物可用于各种生物医学应用。本文综述了四种常用的聚合物表面改性方法:激光处理、离子注入、等离子体处理和纳米粒子接枝。研究了表面处理引起的各种聚合物基质的物理化学性质、形态、化学组成和生物相容性的变化。相关的生物学方法被用来确定各种表面处理和接枝工艺对新表面的生物相容性的影响,研究了哺乳动物细胞的粘附和增殖,以及表面处理的聚合物基底在生物医学工业中的其他潜在应用。
While polymers are widely utilized materials in the biomedical industry, they are rarely used in an unmodified state. Some kind of a surface treatment is often necessary to achieve properties suitable for specific applications. There are multiple methods of surface treatment, each with their own pros and cons, such as plasma and laser treatment, UV lamp modification, etching, grafting, metallization, ion sputtering and others. An appropriate treatment can change the physico-chemical properties of the surface of a polymer in a way that makes it attractive for a variety of biological compounds, or, on the contrary, makes the polymer exhibit antibacterial or cytotoxic properties, thus making the polymer usable in a variety of biomedical applications. This review examines four popular methods of polymer surface modification: laser treatment, ion implantation, plasma treatment and nanoparticle grafting. Surface treatment-induced changes of the physico-chemical properties, morphology, chemical composition and biocompatibility of a variety of polymer substrates are studied. Relevant biological methods are used to determine the influence of various surface treatments and grafting processes on the biocompatibility of the new surfaces—mammalian cell adhesion and proliferation is studied as well as other potential applications of the surface-treated polymer substrates in the biomedical industry.
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