A prospective cohort study of physical activity and time to pregnancy.
A prospective cohort study of physical activity and time to pregnancy.
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DOI：
10.1016/j.fertnstert.2012.02.025
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发表时间：
2012-05
影响因子：
6.7
通讯作者：
Hatch, Elizabeth E.
中科院分区：
文献类型：
--
作者：
Wise, Lauren A.;Rothman, Kenneth J.;Mikkelsen, Ellen M.;Sorensen, Henrik Toft;Riis, Anders H.;Hatch, Elizabeth E.
目的：探讨闲暇体力活动(PA)与受精率的关系。前瞻性队列研究。对计划怀孕的丹麦妇女进行的基于互联网的观察性研究(2007-2009年)。基线年龄为18-40岁的3628名妇女。没有。怀孕时间(TTP)。受精率(FR)和95%可信区间(CI)来自离散时间COX模型，并调整了潜在的混杂因素，如体重指数(BMI)。在两种PA类型的相互调整后，我们观察到强烈的PA与受精性之间呈反单调关系(≥为5小时/周与无：FR=0.68，95%CI：0.54，0.85)，而中等PA与受精性(≥5与每周1小时：FR=1.18，95%CI：0.98，1.43)之间存在微弱的正相关。在年龄、产次状况和周期规律性的亚组中，观察到高活力的PA与生殖力之间的负相关，但在超重或肥胖女性(体重指数≥为25公斤/平方米)中没有观察到这种关联。有证据表明，除了超重和肥胖女性外，在所有女性亚组中，活跃的PA增加和延迟的TTP之间存在剂量-反应关系。无论体重指数如何，适中的PA与受精率的小幅增加有关。这些发现表明，任何类型的PA都可以提高超重和肥胖女性的生育力，这两个群体是不孕不育风险较高的一个亚群。苗条的女性用适中的PA代替强健的PA也可能提高她们的生育力。
To investigate the association between leisure-time physical activity (PA) and fecundability. Prospective cohort study. Internet-based observational study of Danish women who were planning a pregnancy (2007–2009). 3,628 women aged 18–40 years at baseline. None. Time-to-pregnancy (TTP). Fecundability ratios (FR) and 95% confidence intervals (CI) were derived from discrete-time Cox models, with adjustment for potential confounders such as body mass index (BMI). We observed an inverse monotonic association between vigorous PA and fecundability (≥5 hours/week vs. none: FR=0.68, 95% CI: 0.54, 0.85), and a weak positive association between moderate PA and fecundability (≥5 vs. <1 hours/week: FR=1.18, 95% CI: 0.98, 1.43), after mutual adjustment for both PA types. Inverse associations between high vigorous PA and fecundability were observed within subgroups of age, parity status, and cycle regularity, but not among overweight or obese women (BMI ≥ 25 kg/m2). There was evidence for a dose-response relation between increasing vigorous PA and delayed TTP in all subgroups of women, with the exception of overweight and obese women. Moderate PA was associated with a small increase in fecundability regardless of BMI. These findings indicate that PA of any type might improve fertility among overweight and obese women, a subgroup at higher risk of infertility. Lean women who substitute vigorous PA with moderate PA may also improve their fertility.
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影响因子：
2
作者：
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通讯作者：
SIMON, R
影响因子：
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通讯作者：
WEINBERG, CR