Structural correlates of atypical visual and motor cortical oscillations in pediatric-onset multiple sclerosis.
Structural correlates of atypical visual and motor cortical oscillations in pediatric-onset multiple sclerosis.
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DOI：
10.1002/hbm.25126
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发表时间：
2020-10-15
影响因子：
4.8
通讯作者：
Gaetz WC
中科院分区：
文献类型：
--
作者：
Waldman AT;Sollee JR;Datta R;Lavery AM;Liu G;Aleman TS;Banwell BL;Gaetz WC
我们之前已经证明，儿童发病的多发性硬化症（POMS）会对视觉通路和运动处理速度产生负面影响。与 MS 相关的灰质和白质 (WM) 组织弥漫性结构损伤与皮质对视觉和运动刺激的反应之间的关系仍知之甚少。我们在 14 名 POMS 患者和 15 名年龄和性别匹配的健康对照中使用脑磁图来评估视觉伽玛（30-80赫兹）、运动伽玛（60-90赫兹）和运动贝塔（15-30赫兹）皮层对视觉运动任务的振荡反应。然后，3T MRI 用于：（a）计算后视觉和皮质脊髓运动 WM 通路的分数各向异性（FA），以及（b）量化楔骨和初级运动皮层的体积和厚度。 POMS 中视觉伽马带功率降低，与视辐射 FA 降低相关，但与楔骨体积或厚度损失无关。 POMS 中初级运动皮层的活动（通过与峰值潜伏期相关的运动后 β 反弹幅度测量）有所减少，尽管这种减少并未通过结构指标预测。我们的研究结果表明 WM 完整性的丧失是导致 POMS 视觉皮层电反应减少的一个因素。未来在更大队列中的研究将揭示这一发现对视觉处理功能的认知影响，并将确定 POMS 中已知发生的脑容量逐渐丧失是否最终导致此类任务中的进行性功能障碍以及视觉皮层中皮层电反应的逐渐减少。我们在 14 名小儿多发性硬化症 (POMS) 患者和 15 名年龄和性别匹配的健康对照中使用脑磁图来评估视觉伽玛 (30–80Hz)、运动伽玛 (60–90Hz) 和运动 β (15–30Hz) 皮质振荡对视觉运动任务的反应。 3T MRI 用于：(a) 计算后视觉和皮质脊髓运动 WM 通路的分数各向异性 (FA)，以及 (b) 量化楔叶和初级运动皮层的体积和厚度。 POMS 中视觉伽马带功率降低，与视辐射 FA 降低相关，但与楔骨体积或厚度损失无关。
We have previously demonstrated that pediatric‐onset multiple sclerosis (POMS) negatively impacts the visual pathway as well as motor processing speed. Relationships between MS‐related diffuse structural damage of gray and white matter (WM) tissue and cortical responses to visual and motor stimuli remain poorly understood. We used magnetoencephalography in 14 POMS patients and 15 age‐ and sex‐matched healthy controls to assess visual gamma (30–80 Hz), motor gamma (60–90 Hz), and motor beta (15–30 Hz) cortical oscillatory responses to a visual‐motor task. Then, 3T MRI was used to: (a) calculate fractional anisotropy (FA) of the posterior visual and corticospinal motor WM pathways and (b) quantify volume and thickness of the cuneus and primary motor cortex. Visual gamma band power was reduced in POMS and was associated with reduced FA of the optic radiations but not with loss of cuneus volume or thickness. Activity in the primary motor cortex, as measured by postmovement beta rebound amplitude associated with peak latency, was decreased in POMS, although this reduction was not predicted by structural metrics. Our findings implicate loss of WM integrity as a contributor to reduced electrical responses in the visual cortex in POMS. Future work in larger cohorts will inform on the cognitive implications of this finding in terms of visual processing function and will determine whether the progressive loss of brain volume known to occur in POMS ultimately contributes to both progressive dysfunction in such tasks as well as progressive reduction in cortical electrical responses in the visual cortex. We used magnetoencephalography in 14 pediatric‐onset multiple sclerosis (POMS) patients and 15 age‐ and sex‐matched healthy controls to assess visual gamma (30–80 Hz), motor gamma (60–90 Hz), and motor beta (15–30 Hz) cortical oscillatory responses to a visual‐motor task. 3T MRI was used to: (a) calculate fractional anisotropy (FA) of the posterior visual and corticospinal motor WM pathways and (b) quantify volume and thickness of the cuneus and primary motor cortex. Visual gamma band power was reduced in POMS and was associated with reduced FA of the optic radiations but not with loss of cuneus volume or thickness.
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衰老大脑的功能和结构相关性：将视觉皮层（V1）伽马条带对与年龄相关的结构变化的响应。
影响因子：
4.8
作者：
Gaetz, William;Roberts, Timothy P. L.;Singh, Krish D.;Muthukumaraswamy, Suresh D.
通讯作者：
Muthukumaraswamy, Suresh D.
DOI：
10.1093/brain/aws242
发表时间：
2012-10
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Kolasinski J;Stagg CJ;Chance SA;Deluca GC;Esiri MM;Chang EH;Palace JA;McNab JA;Jenkinson M;Miller KL;Johansen-Berg H
通讯作者：
Johansen-Berg H
影响因子：
4.8
作者：
Arpin, David J.;Heinrichs-Graham, Elizabeth;Kurz, Max J.
通讯作者：
Kurz, Max J.
影响因子：
11.2
作者：
Gabilondo, Inigo;Martinez-Lapiscina, Elena H.;Villoslada, Pablo
通讯作者：
Villoslada, Pablo
影响因子：
44.1
作者：
HAMALAINEN, M;HARI, R;LOUNASMAA, OV
通讯作者：
LOUNASMAA, OV