Sodium exposure induces stroke in a genetically susceptible model: new insights into early-life factors modulating adult disease.
Sodium exposure induces stroke in a genetically susceptible model: new insights into early-life factors modulating adult disease.
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钠暴露在遗传易感模型中诱发中风：对调节成人疾病的早期生命因素的新见解。
DOI：
10.1161/circulationaha.109.849554
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发表时间：
2009
期刊：
影响因子：
37.8
通讯作者：
Palinski,Wulf
中科院分区：
文献类型：
--
作者：
Palinski,Wulf
自从Barker和他的同事们首次提出子宫内的条件会影响以后生活中对疾病的易感性以来，已经取得了很大的进展。1广泛的流行病学研究已经证实胎儿生长迟缓与成人高血压、心血管疾病和糖尿病之间存在关联。2，3人们还认识到，为了预防致病性编程，我们需要确定和针对特定的孕产妇因素或条件，并且西方世界普遍存在孕产妇营养过剩，而不是营养不足。已经确定了几个这样的因素（例如，母亲高胆固醇血症，4-6吸烟，7和糖尿病8），并开发了实验模型，其中可以研究发育编程的机制和因果关系。最后，母亲或环境因素对成人疾病的影响现在被广泛接受，肥胖、高血脂和糖尿病母亲的儿童心血管疾病的预期导致美国国会和国立卫生研究院高度重视特定风险因素的阐明（例如，在国家儿童研究中9）。动物模型是确定所涉及的机制和找到预防方法的关键，这些方法不仅仅是避免怀孕期间的风险或治疗母体代谢异常。
Much progress has been made since Barker and col-leagues first proposed that conditions in utero influence the susceptibility to disease later in life. 1 The association between fetal growth retardation and adult hypertension, cardiovascular disease and diabetes mellitus has been established by extensive epidemiology. 2, 3 It has also been recognized that in order to prevent pathogenic programming we need to identify and target specific maternal factors or conditions, and that maternal overnutrition, rather than undernutrition, is prevalent in the Western world. Several such factors have already been established (eg, maternal hypercholesterolemia, 4–6 smoking, 7 and diabetes mellitus8) and experimental models have been developed in which mechanisms and causal relationships of developmental programming can be investigated. Finally, the influence of maternal or environmental factors on adult disease is now widely accepted, and the expectation of a wave of cardiovascular disease in children of obese, hyperlipidemic, and diabetic mothers has led the US Congress and the National Institutes of Health to place great emphasis on the elucidation of specific risk factors (eg, in the National Children’s Study9). Animal models are key to identifying the mechanisms involved and finding preventive approaches that go beyond simple avoidance of risk during pregnancy or treatment of maternal dysmetabolic conditions.
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影响因子：
7.7
作者：
Dabelea, D;Hanson, RL;Knowler, WC
通讯作者：
Knowler, WC
影响因子：
20.1
作者：
Palinski, W;D'Armiento, FP;Napoli, C
通讯作者：
Napoli, C
影响因子：
8.3
作者：
DINICOLANTONIO, R;HOY, K;MORGAN, TO
通讯作者：
MORGAN, TO
影响因子：
15.9
作者：
Napoli, C;D'Armiento, FP;Palinski, W
通讯作者：
Palinski, W
影响因子：
37.8
作者：
Koukkou, E;Ghosh, P;Poston, L
通讯作者：
Poston, L