Functional and anatomical connectivity abnormalities in left inferior frontal gyrus in schizophrenia.
Functional and anatomical connectivity abnormalities in left inferior frontal gyrus in schizophrenia.
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DOI：
10.1002/hbm.20835
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发表时间：
2009-12
影响因子：
4.8
通讯作者：
Kubicki, Marek
中科院分区：
文献类型：
--
作者：
Jeong, Bumseok;Wible, Cynthia G.;Hashimoto, Ryu-ichiro;Kubicki, Marek
精神分裂症患者的功能研究显示，左侧额下回（IFG）存在明显的异常，同时提示在语义加工过程中，包括左侧IFG和上级颞回在内的语言网络存在功能连接异常。在精神分裂症中，语义网络中涉及的区域之间的白色物质连接也被指出。然而，在精神分裂症的语义网络内的功能和解剖连接中断之间的关联尚未建立。采集并分析了10名对照者和10名慢性精神分裂症患者的功能（使用处理水平范式）以及扩散张量成像数据。首先，语义编码特定的激活估计，显示在左IFG的精神分裂症激活减少。其次，从该区域提取功能时间序列，并为每个受试者制作左IFG特定功能连接图。在一项独立分析中，使用基于区域的空间统计（TBSS）来比较各组之间的各向异性分数（FA）值，并将这些值与功能连接图相关联。精神分裂症患者在包括左侧IFG和左侧上级颞沟/颞中回在内的语言网络中表现出较弱的功能连接。FA在几个白色区域减少，包括左额下和左内囊。最后，左下额叶白色物质FA与精神分裂症患者语义网络的连接性指标呈正相关，但在对照组中不相关。我们的研究结果表明，在精神分裂症的语义网络的解剖和功能连接异常之间的关联，进一步表明，在这种疾病中观察到的功能异常可能直接相关的白色物质中断。
Functional studies in schizophrenia demonstrate prominent abnormalities within the left inferior frontal gyrus(IFG) and also suggest the functional connectivity abnormalities in language network including left IFG and superior temporal gyrus during semantic processing. White matter connections between regions involved in the semantic network have also been indicated in schizophrenia. However, an association between functional and anatomical connectivity disruptions within the semantic network in schizophrenia has not been established. Functional (using Levels of Processing paradigm) as well as Diffusion Tensor Imaging data from 10 controls and 10 chronic schizophrenics were acquired and analyzed. First, semantic encoding specific activation was estimated, showing decreased activation within the left IFG in schizophrenia. Second, functional time series were extracted from this area, and left IFG specific functional connectivity maps were produced for each subject. In an independent analysis, Tract-Based Spatial Statistics(TBSS) was used to compare Fractional Anisotropy(FA) values between groups, and to correlate these values with functional connectivity maps. Schizophrenia patients showed weaker functional connectivity within the language network that includes left IFG and left superior temporal sulcus/middle temporal gyrus. FA was reduced in several white matter regions including left inferior frontal and left internal capsule. Finally, left inferior frontal white matter FA was positively correlated with connectivity measures of the semantic network in schizophrenics, but not in controls. Our results indicate an association between anatomical and functional connectivity abnormalities within the semantic network in schizophrenia, suggesting further that the functional abnormalities observed in this disorder might be directly related to white matter disruptions.
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