Current Understanding of Circular RNAs in Systemic Lupus Erythematosus.
Current Understanding of Circular RNAs in Systemic Lupus Erythematosus.
复制标题
系统性红斑狼疮中环状 RNA 的最新认识
DOI：
10.3389/fimmu.2021.628872
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Guo J
中科院分区：
文献类型：
--
作者：
Liu H;Zou Y;Chen C;Tang Y;Guo J
系统性红斑狼疮（SLE）是一种常见的和潜在的致命性自身免疫性疾病，影响多个器官。迄今为止，其病因和发病机制仍不清楚。环状RNA（CircRNA）是一类新型的内源性非编码RNA，具有共价闭环结构。越来越多的证据表明，circRNA可能通过充当microRNA（miRNA）海绵，通过与RNA结合蛋白（RBP）相互作用影响细胞存活和增殖，以及通过形成RNA-蛋白质复合物双链体结构来增强mRNA稳定性，在基因表达和转录调控中发挥重要作用。circRNA的表达模式具有组织特异性和发病相关性。CircRNA参与多种自身免疫性疾病的发展，包括SLE。本文综述了circRNA的特征、生物起源、潜在功能及其对免疫应答的影响，并重点介绍了circRNA在SLE发病机制中的作用。
Systemic lupus erythematosus (SLE) is a common and potentially fatal autoimmune disease that affects multiple organs. To date, its etiology and pathogenesis remains elusive. Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs with covalently closed loop structure. Growing evidence has demonstrated that circRNAs may play an essential role in regulation of gene expression and transcription by acting as microRNA (miRNA) sponges, impacting cell survival and proliferation by interacting with RNA binding proteins (RBPs), and strengthening mRNA stability by forming RNA-protein complexes duplex structures. The expression patterns of circRNAs exhibit tissue-specific and pathogenesis-related manner. CircRNAs have implicated in the development of multiple autoimmune diseases, including SLE. In this review, we summarize the characteristics, biogenesis, and potential functions of circRNAs, its impact on immune responses and highlight current understanding of circRNAs in the pathogenesis of SLE.
登录
查看更多内容
与2型糖尿病患者炎症相关的环状RNA的筛选和circANKRD36的验证
影响因子：
5.4
作者：
Fang Y;Wang X;Li W;Han J;Jin J;Su F;Zhang J;Huang W;Xiao F;Pan Q;Zou L
通讯作者：
Zou L
影响因子：
14.9
作者：
Enuka Y;Lauriola M;Feldman ME;Sas-Chen A;Ulitsky I;Yarden Y
通讯作者：
Yarden Y
环状 RNA 测序确定 CircASAP1 是肝细胞癌转移的关键调节因子。
影响因子：
13.5
作者：
Hu, Zhi-Qiang;Zhou, Shao-Lai;Zhou, Jian
通讯作者：
Zhou, Jian
影响因子：
4.6
作者：
Abe N;Matsumoto K;Nishihara M;Nakano Y;Shibata A;Maruyama H;Shuto S;Matsuda A;Yoshida M;Ito Y;Abe H
通讯作者：
Abe H
影响因子：
4.8
作者：
COCQUERELLE, C;MASCREZ, B;BAILLEUL, B
通讯作者：
BAILLEUL, B