Total Serum Testosterone and Western Ontario and McMaster Universities Osteoarthritis Index Pain and Function Among Older Men and Women With Severe Knee Osteoarthritis.
Total Serum Testosterone and Western Ontario and McMaster Universities Osteoarthritis Index Pain and Function Among Older Men and Women With Severe Knee Osteoarthritis.
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DOI：
10.1002/acr.24074
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发表时间：
2020-11
影响因子：
4.7
通讯作者：
Bischoff-Ferrari HA
中科院分区：
文献类型：
--
作者：
Freystaetter G;Fischer K;Orav EJ;Egli A;Theiler R;Münzer T;Felson DT;Bischoff-Ferrari HA
研究血清总睾丸激素水平是否与患有严重膝关节骨关节炎（OA）的男性和女性的膝盖疼痛和功能有关。
我们招募了272名成年人≥60岁（平均±SD年龄70.4±4.4岁，53％的妇女）由于严重的膝盖OA而进行了单侧总膝盖替代（TKR）手术膝盖，有56％的参与者有具有Kellgren/Lawrence级≥2的射线照相OA，使用对年龄，体育活动和BMI的多变量回归进行了性别和体重指数（BMI）亚组。
在手术膝盖上，较高的睾丸激素水平与男性的妇女疼痛较小（B = –0.62，P = 0.046）和女性（B = –3.79，P = 0.02），女性的WOMAC残疾分数较小（B = –3.62，P = 0.02），P = 0.02）和肥胖男性（B = –1.99级别的女性，妇女均与妇女相关联。睾丸激素水平是与女性的残疾较少有关（B = –0.95，p = 0.02）。
较高的总睾丸激素水平与患有TKR的男性和女性的膝盖疼痛较小，而在非手术的膝盖中，较高的睾丸激素水平与较高的睾丸激素水平与疼痛和残疾较少相关。
To investigate whether serum total testosterone level is associated with knee pain and function in men and women with severe knee osteoarthritis (OA). We enrolled 272 adults age ≥60 years (mean ± SD age 70.4 ± 4.4 years, 53% women) who underwent unilateral total knee replacement (TKR) due to severe knee OA. Serum testosterone levels and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function of the operated and contralateral knee were measured at 6–8 weeks after surgery. At the nonoperated knee, 56% of participants had radiographic knee OA with a Kellgren/Lawrence grade ≥2. Cross‐sectional analyses were performed by sex and body mass index (BMI) subgroups, using multivariable regression adjusted for age, physical activity, and BMI. At the operated knee, higher testosterone levels were associated with less WOMAC pain in men (B = –0.62, P = 0.046) and women (B = –3.79, P = 0.02), and less WOMAC disability scores in women (B = –3.62, P = 0.02) and obese men (B = –1.99, P = 0.02). At the nonoperated knee, testosterone levels were not associated with WOMAC pain in men or women, but higher testosterone levels were associated with less disability in women (B = –0.95, P = 0.02). Testosterone levels were inconsistently associated with pain and disability in BMI subgroups among men. Only among obese women, testosterone levels were inversely associated with radiographic knee OA (odds ratio = 0.10, P = 0.003). Higher total testosterone levels were associated with less pain in the operated knee in men and women undergoing TKR and less disability in women. At the nonoperated knee, higher testosterone levels were inconsistently associated with less pain and disability.
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影响因子：
5
作者：
FELSON, DT
通讯作者：
FELSON, DT
影响因子：
27.4
作者：
Günther, KP;Stürmer, T;Puhl, W
通讯作者：
Puhl, W
影响因子：
5.5
作者：
Brazier, JE;Harper, R;Snaith, ML
通讯作者：
Snaith, ML
影响因子：
4
作者：
Bischoff-Ferrari, H. A.;Orav, E. J.;Dawson-Hughes, B.
通讯作者：
Dawson-Hughes, B.
DOI：
10.1093/gerona/gls068
发表时间：
2012-11-01
影响因子：
5.1
作者：
Horstman, Astrid M.;Dillon, E. Lichar;Sheffield-Moore, Melinda
通讯作者：
Sheffield-Moore, Melinda