Dorsolateral prefrontal cortex magnetic resonance imaging measurements and cognitive performance in autism.
Dorsolateral prefrontal cortex magnetic resonance imaging measurements and cognitive performance in autism.
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DOI：
10.1177/0883073809351313
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发表时间：
2010-07
影响因子：
1.9
通讯作者：
Hardan A
中科院分区：
文献类型：
--
作者：
Griebling J;Minshew NJ;Bodner K;Libove R;Bansal R;Konasale P;Keshavan MS;Hardan A
本研究旨在探讨自闭症患者额叶结构的体积测量与执行功能任务表现之间的关系。MRI扫描来自38名自闭症患者和40名年龄在8至45岁之间的匹配对照。执行功能评估采用神经心理学的措施，包括威斯康星州卡片分类测试和河内塔。两组在神经心理测试上的表现存在差异。然而，两组之间没有观察到背外侧前额叶皮质体积的差异。没有发现体积测量与神经心理测试表现之间存在相关性。这项研究的结果表明，自闭症中观察到的执行功能缺陷与额叶的功能异常有关，但与解剖异常无关。相关性的缺乏表明，执行功能障碍不是局部脑改变的结果，而是分布式神经网络功能障碍的结果。
This study examined the relationships between volumetric measurements of frontal lobe structures and performance on executive function tasks in individuals with autism. MRI scans were obtained from 38 individuals with autism and 40 matched controls between the ages of 8 and 45 years. Executive function was assessed using neuropsychological measures including the Wisconsin Card Sorting Test and Tower of Hanoi. Differences in performance on the neuropsychological tests were found between the two groups. However, no differences in dorsolateral prefrontal cortex volumes were observed between groups. No correlations between volumetric measurements and performance on the neuropsychological tests were found. Findings from this study suggest that executive function deficits observed in autism are related to functional but not anatomical abnormalities of the frontal lobe. The absence of correlations suggests that executive dysfunction is not the result of focal brain alterations but, rather, is the result of a distributed neural network dysfunction.
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影响因子：
2.6
作者：
BORYS, SV;SPITZ, HH;DORANS, BA
通讯作者：
DORANS, BA
影响因子：
5.7
作者：
Carper, RA;Moses, P;Courchesne, E
通讯作者：
Courchesne, E
影响因子：
9.9
作者：
Aylward, EH;Minshew, NJ;Singh, N
通讯作者：
Singh, N
DOI：
10.1080/01688638608401314
发表时间：
1986-06-01
影响因子：
2.2
作者：
CHELUNE, GJ;BAER, RA
通讯作者：
BAER, RA
影响因子：
1.9
作者：
Davidovitch, M;Patterson, B;Gartside, P
通讯作者：
Gartside, P