Frontal-Sensory Cortical Projections Become Dispensable for Attentional Performance Upon a Reduction of Task Demand in Mice.
Frontal-Sensory Cortical Projections Become Dispensable for Attentional Performance Upon a Reduction of Task Demand in Mice.
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DOI：
10.3389/fnins.2021.775256
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发表时间：
2021
影响因子：
4.3
通讯作者：
Morishita H
中科院分区：
文献类型：
--
作者：
Norman KJ;Bateh J;Maccario P;Cho C;Caro K;Nishioka T;Koike H;Morishita H
自上而下的注意是一种动态的认知过程，有助于我们从复杂的感官环境中检测与任务相关的刺激。一个能够在特定任务需求条件下部署的神经机制将是至关重要的，以有效地控制注意过程，并在波动的注意需求，提高促进目标导向的注意性能。已有研究表明，小鼠在5-选择系列反应时任务（5CSRTT）中，前扣带区（ACA）向视皮层（维斯; ACA维斯）的自上而下投射神经元是视觉注意行为所必需的。然而，目前尚不清楚这些投射神经元的贡献是否取决于任务需求的程度。在这里，我们首先研究了行为结果如何取决于小鼠注意和触摸成功表现的位置的数量，并发现2-选择系列反应时间任务（2CSRTT）比5CSRTT的任务要求更低。然后，我们采用光遗传学来证明，在2CSRTT期间，与在5CSRTT期间受损的表现相比，在刺激呈现之前立即抑制ACAVIS投射没有影响。这些结果表明，当任务要求高时，ACAVIS投射是必要的，但一旦任务要求降低，ACAVIS神经元活动变得不稳定，以调节注意力的表现。这些发现支持了一个模型，即在特定的高任务需求条件下，额叶感觉ACAVIS投射调节视觉注意行为，指出一个灵活的基于电路的机制，促进注意行为。
Top-down attention is a dynamic cognitive process that facilitates the detection of the task-relevant stimuli from our complex sensory environment. A neural mechanism capable of deployment under specific task-demand conditions would be crucial to efficiently control attentional processes and improve promote goal-directed attention performance during fluctuating attentional demand. Previous studies have shown that frontal top-down neurons projecting from the anterior cingulate area (ACA) to the visual cortex (VIS; ACAVIS) are required for visual attentional behavior during the 5-choice serial reaction time task (5CSRTT) in mice. However, it is unknown whether the contribution of these projecting neurons is dependent on the extent of task demand. Here, we first examined how behavior outcomes depend on the number of locations for mice to pay attention and touch for successful performance, and found that the 2-choice serial reaction time task (2CSRTT) is less task demanding than the 5CSRTT. We then employed optogenetics to demonstrate that suppression ACAVIS projections immediately before stimulus presentation has no effect during the 2CSRTT in contrast to the impaired performance during the 5CSRTT. These results suggest that ACAVIS projections are necessary when task demand is high, but once a task demand is lowered, ACAVIS neuron activity becomes dispensable to adjust attentional performance. These findings support a model that the frontal-sensory ACAVIS projection regulates visual attention behavior during specific high task demand conditions, pointing to a flexible circuit-based mechanism for promoting attentional behavior.
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精神分裂症认知临床前模型的新转化测定：小鼠和大鼠的触摸屏测试方法。
影响因子：
4.7
作者：
Bussey TJ;Holmes A;Lyon L;Mar AC;McAllister KA;Nithianantharajah J;Oomen CA;Saksida LM
通讯作者：
Saksida LM
影响因子：
2.5
作者：
Norman KJ;Koike H;McCraney SE;Garkun Y;Bateh J;Falk EN;Im S;Caro K;Demars MP;Morishita H
通讯作者：
Morishita H
影响因子：
2.7
作者：
CARLI, M;ROBBINS, TW;EVERITT, BJ
通讯作者：
EVERITT, BJ
选择性关注。远程和本地电路，用于自上而下的视觉皮层处理。
DOI：
10.1126/science.1254126
发表时间：
2014-08-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Zhang S;Xu M;Kamigaki T;Hoang Do JP;Chang WC;Jenvay S;Miyamichi K;Luo L;Dan Y
通讯作者：
Dan Y
影响因子：
16.2
作者：
Norman KJ;Riceberg JS;Koike H;Bateh J;McCraney SE;Caro K;Kato D;Liang A;Yamamuro K;Flanigan ME;Kam K;Falk EN;Brady DM;Cho C;Sadahiro M;Yoshitake K;Maccario P;Demars MP;Waltrip L;Varga AW;Russo SJ;Baxter MG;Shapiro ML;Rudebeck PH;Morishita H
通讯作者：
Morishita H