Cellular and developmental basis of orofacial clefts.
Cellular and developmental basis of orofacial clefts.
复制标题
DOI：
10.1002/bdr2.1768
复制
发表时间：
2020-11
影响因子：
2.1
通讯作者：
Zhou CJ
中科院分区：
文献类型：
--
作者：
Ji Y;Garland MA;Sun B;Zhang S;Reynolds K;McMahon M;Rajakumar R;Islam MS;Liu Y;Chen Y;Zhou CJ
在颅面发育过程中，上唇和/或上颚的生长和融合缺陷可导致口面裂（OFCs），这是人类最常见的结构性出生缺陷之一。OFCs的发育基础包括上唇、初级上颚、次级上颚和其他口面结构的形态发生，每个结构都由源自三种胚层（外胚层、中胚层和内胚层）的不同细胞类型组成。颅神经嵴细胞和口面上皮细胞是两种主要的细胞类型，它们与各种细胞系相互作用，在口面发育中起着关键作用。OFCs的细胞基础涉及以下任何一个或几个过程的缺陷执行：神经嵴诱导、上皮-间质转化、迁移、增殖、分化、凋亡、初级纤毛形成及其信号转导、上皮缝形成和消失、周皮形成和剥离、腭上皮缝细胞的收敛和挤压、细胞粘附、细胞骨架动力学和细胞外基质功能。最新的细胞和发育发现可能为更好地理解OFCs的潜在遗传、表观遗传、环境和分子机制提供基础。
During craniofacial development, defective growth and fusion of the upper lip and/or palate can cause orofacial clefts (OFCs), which are among the most common structural birth defects in humans. The developmental basis of OFCs includes morphogenesis of the upper lip, primary palate, secondary palate, and other orofacial structures, each of which consisting of diverse cell types originating from all three germ layers: the ectoderm, mesoderm, and endoderm. Cranial neural crest cells and orofacial epithelial cells are two major cell types that interact with various cell lineages and play key roles in orofacial development. The cellular basis of OFCs involves defective execution in any one or several of the following processes: neural crest induction, epithelial-mesenchymal transition, migration, proliferation, differentiation, apoptosis, primary cilia formation and its signaling transduction, epithelial seam formation and disappearance, periderm formation and peeling, convergence and extrusion of palatal epithelial seam cells, cell adhesion, cytoskeleton dynamics, and extracellular matrix function. The latest cellular and developmental findings may provide a basis for better understanding of the underlying genetic, epigenetic, environmental, and molecular mechanisms of OFCs.
登录
查看更多内容
影响因子：
3.3
作者：
Blavier, L;Lazaryev, A;Kaartinen, V
通讯作者：
Kaartinen, V
影响因子：
3.5
作者：
Brugmann, Samantha A.;Allen, Nancy C.;Helms, Jill A.
通讯作者：
Helms, Jill A.
影响因子：
7.6
作者：
Brown, NL;Yarram, SJ;Sandy, JR
通讯作者：
Sandy, JR
影响因子：
3
作者：
ADS, AH;PIDDINGTON, R;HEROLD, R
通讯作者：
HEROLD, R
影响因子：
2.9
作者：
Ba, Hengxing;Wang, Datao;Li, Chunyi
通讯作者：
Li, Chunyi