The relationship between combat-related posttraumatic stress disorder and the 5-HTTLPR/rs25531 polymorphism.
The relationship between combat-related posttraumatic stress disorder and the 5-HTTLPR/rs25531 polymorphism.
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DOI：
10.1002/da.20872
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发表时间：
2011-12-21
影响因子：
7.4
通讯作者：
Amstadter, Ananda
中科院分区：
文献类型：
--
作者：
Wang, Zhewu;Baker, Dewleen G.;Harrer, Judith;Hamner, Mark;Price, Matthew;Amstadter, Ananda
关键词：
经验证据表明，在创伤后应激障碍（PTSD）的发展中存在显著的遗传影响。5-羟色胺转运体（5-HTT）基因（SLC6A4）已被确定为该疾病发展的主要候选者，因为5-HTT是选择性5-羟色胺再摄取抑制剂（SSRIs）的工作靶点，这是PTSD的一线治疗药物。一些研究报道了平民样本中5-HTTLPR启动子区（5-HTTLPR）多态性变异与PTSD发病率增加之间的关联。本研究调查了5-HTTLPR多态性在有和没有创伤后应激障碍的退伍军人样本中的作用。在388名退伍军人的样本中，研究人员检查了三种基因型的PTSD发病率。对5-HTTLPR的长/短多态性和5-HTTLPR内的A-G多态性（rs25531）进行基因分型，并进行统计学分析。5- httlpr /rs25531基因型频率组间（PTSD与非PTSD）差异有统计学意义（χ2[1, n=388]=16.23， P=5.62×10−5）。在228名有战斗严重程度数据的参与者中，5-HTTLPR S ' /S '（低转录效率）基因型也与PTSD严重程度评分相关（r= 0.15， P=0.03）。这一发现与先前在平民人群中的研究一致，该研究表明5-HTTLPR的低转录效率S ‘ /S ’基因型是创伤暴露后PTSD发展的危险因素。我们的发现是第一次在军队样本中研究这种多态性和创伤后应激障碍。需要更多的大规模调查来重复这些发现。
Empirical evidence suggests that there is a significant genetic influence in the development of posttraumatic stress disorder (PTSD). The serotonin transporter (5-HTT) gene (SLC6A4) has been identified as a prime candidate for the development of the disorder, as 5-HTT is a working target for selective serotonin reuptake inhibitors (SSRIs), first line treatment agents for PTSD. Several studies have reported associations between 5-HTT-linked promoter region (5-HTTLPR) polymorphism variants and increased rates of PTSD in civilian samples. This study investigated the role of the 5-HTTLPR polymorphism, triallelically classified, in a sample of combat veterans with and without PTSD. Rates of PTSD were examined across three genotypes in a sample of 388 combat veterans. The short/long polymorphism of 5-HTTLPR and the A-G polymorphism within the 5-HTTLPR (rs25531) were genotyped, and statistical analyses were conducted. There were significant intergroup (PTSD versus non-PTSD) differences in the genotype frequencies of 5-HTTLPR/rs25531 (χ2[1, n=388]=16.23, P=5.62×10−5). The 5-HTTLPR S′/S′ (low transcriptionally efficient) genotype was also associated with the PTSD severity score in the 228 participants who had combat severity data (r=.15, P=0.03). The findings are consistent with previous research among civilian populations that have indicated that the low transcriptionally efficient S′/S′ genotype of 5-HTTLPR is a risk factor for the development of PTSD after trauma exposure. Our findings are the first to examine this polymorphism and PTSD in a military sample. Additional large-scale investigations are needed to replicate these findings.
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影响因子：
3.3
作者：
Koenen, Karestan C.;Amstadter, Ananda B.;Nugent, Nicole R.
通讯作者：
Nugent, Nicole R.
影响因子：
17.7
作者：
Kilpatrick, Dean G.;Koenen, Karestan C.;Gelernter, Joel
通讯作者：
Gelernter, Joel
影响因子：
--
作者：
TRUE, WR;RICE, J;NOWAK, J
通讯作者：
NOWAK, J
影响因子：
5.3
作者：
Sheehan, DV;Lecrubier, Y;Dunbar, GC
通讯作者：
Dunbar, GC
影响因子：
7.4
作者：
Lee, HJ;Lee, MS;Paik, IH
通讯作者：
Paik, IH