Recent progress and perspectives of continuous in vivo testing device.
Recent progress and perspectives of continuous in vivo testing device.
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DOI：
10.1016/j.mtbio.2022.100341
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发表时间：
2022-12
影响因子：
8.2
通讯作者：
Cai, Xinxia
中科院分区：
文献类型：
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作者：
Ming, Tao;Luo, Jinping;Xing, Yu;Cheng, Yan;Liu, Juntao;Sun, Shuai;Kong, Fanli;Xu, Shihong;Dai, Yuchuan;Xie, Jingyu;Jin, Hongyan;Cai, Xinxia
用于连续体内测试（CIVT）的设备可以真实的实时检测目标物质，从而提供了一个有价值的窗口，以了解患者的状况、他们对治疗剂的反应、代谢活动和大脑中的神经递质传递。因此，CIVT设备受到越来越多的关注，因为它们有望极大地帮助疾病诊断和治疗以及对人类发病机制的研究。然而，仅对少数标志物实现了CIVT，并且检测许多关键标志物仍然具有挑战性。因此，对CIVT的关键技术和方法进行总结，并探讨其未来的发展方向具有重要意义。我们回顾了CIVT器件的发展，考虑到这些设备的结构，连续检测的原则，和用于电极修饰的纳米材料的最新进展。对CIVT设备进行详细而全面的综述有三个目的：（1）总结现有设备的优点和缺点，（2）为CIVT设备的开发提供参考，以检测其他重要标志物，（3）讨论未来的前景，重点是CIVT设备进一步发展必须克服的问题。本文旨在促进CIVT设备的研究进展，并为未来个性化医疗的创新做出贡献。对连续体内试验装置进行了详细和全面的综述。讨论了纳米材料、精细结构和探测原理。总结了现有装置的成就和不足。最后提出了该装置在进一步开发中需要解决的问题和未来的展望。
Devices for continuous in-vivo testing (CIVT) can detect target substances in real time, thus providing a valuable window into a patient's condition, their response to therapeutics, metabolic activities, and neurotransmitter transmission in the brain. Therefore, CIVT devices have received increased attention because they are expected to greatly assist disease diagnosis and treatment and research on human pathogenesis. However, CIVT has been achieved for only a few markers, and it remains challenging to detect many key markers. Therefore, it is important to summarize the key technologies and methodologies of CIVT, and to examine the direction of future development of CIVT. We review recent progress in the development of CIVT devices, with consideration of the structure of these devices, principles governing continuous detection, and nanomaterials used for electrode modification. This detailed and comprehensive review of CIVT devices serves three purposes: (1) to summarize the advantages and disadvantages of existing devices, (2) to provide a reference for development of CIVT equipment to detect additional important markers, and (3) to discuss future prospects with emphasis on problems that must be overcome for further development of CIVT equipment. This review aims to promote progress in research on CIVT devices and contribute to future innovation in personalized medical treatments. A detailed and comprehensive review of continuous in vivo testing device. The nanomaterials, delicate structures and detection principles of the works are discussed. The achievements and shortcomings of the existing devices are summarized. The problems that should be solved in the further development of the devices and the future prospects are put forward.
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影响因子：
19
作者：
Dervisevic, Muamer;Alba, Maria;Voelcker, Nicolas H.
通讯作者：
Voelcker, Nicolas H.
影响因子：
7.4
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Farjami, Elaheh;Campos, Rui;Ferapontova, Elena E.
通讯作者：
Ferapontova, Elena E.
影响因子：
7.4
作者：
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通讯作者：
GOUGH, DA
影响因子：
7.4
作者：
Gao, Weicun;Li, Bo;Xia, Zhiping
通讯作者：
Xia, Zhiping
影响因子：
64.8
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