Genetic association of hypertension and vascular changes in stroke-prone spontaneously hypertensive rats.
Genetic association of hypertension and vascular changes in stroke-prone spontaneously hypertensive rats.
复制标题
易发生中风的自发性高血压大鼠高血压与血管变化的遗传关联。
DOI：
10.1161/01.hyp.8.10.904
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Webb,RC
中科院分区：
文献类型：
--
作者：
Bruner,CA;Myers,JH;Sing,CF;Jokelainen,PT;Webb,RC
Isolated tail arteries from stroke-prone spontaneously hypertensive rats (SHRSP) exhibit oscillatory contractile activity in response to norepinephrine, whereas those from normotensive Wistar-Kyoto rats (WKY) do not. To determine whether the norepinephrine-induced oscillations are related to high blood pressure or to separable genetic differences between strains, the response to norepinephrine was studied in adult SHRSP, WKY, and progeny of genetic crosses of SHRSP and WKY (F1, F2, F1 X SHRSP, F1 X WKY). Helical tail artery strips were mounted in a tissue bath for isometric force recording. Rats were classified as responders if oscillatory activity in the presence of 1.8 X 10(-7) M norepinephrine exceeded 250 mg/10 min (milligrams of force amplitude during a 10-minute interval). The blood pressures (mm Hg +/- SEM; tail cuff method) and percentage of rats exhibiting norepinephrine-induced oscillations were as follows: WKY: 109 +/- 3, 0%; F1: 129 +/- 4, 0%; F2: 150 +/- 4, 38%; F1 X WKY: 137 +/- 3, 9%; F1 X SHRSP: 188 +/- 7, 71%; SHRSP: 207 +/- 7, 100%. The distribution of the frequency of animals with oscillatory activity among the progenies was consistent with the hypothesis that a single gene locus determines the observed difference in oscillatory activity between the WKY and SHRSP strains. The allele from the SHRSP that determines the activity phenotype is recessive to the allele contributed by the normotensive WKY strain. In the segregating F2 progeny, the blood pressure of the responders was higher than that of the nonresponders (161 +/- 6 vs 144 +/- 4 mm Hg; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
登录
查看更多内容
噻吗洛尔治疗的自发性高血压大鼠血管反应性升高。
影响因子：
2.1
作者：
M. Goldberg;C. Triggle
通讯作者：
C. Triggle
影响因子：
20.1
作者：
HANSEN, TR;BOHR, DF
通讯作者：
BOHR, DF
影响因子：
20.1
作者：
L. T. Lais;M. Brody
通讯作者：
M. Brody
血管收缩神经对正常血压和自发性高血压大鼠离体肠系膜阻力血管的影响。
DOI：
10.1111/j.1748-1716.1982.tb07131.x
发表时间：
1982
期刊：
Acta physiologica Scandinavica
影响因子：
--
作者：
H. Nilsson;B. Folkow
通讯作者：
B. Folkow
自发小动脉血管舒缩是外周血管阻力的决定因素。
DOI：
--
发表时间：
1983
期刊：
International journal of microcirculation, clinical and experimental
影响因子：
--
作者：
Funk,W;Endrich,B;Messmer,K;Intaglietta,M
通讯作者：
Intaglietta,M