Air pollution and stillbirth: a population-based case-control study in Taiwan.
Air pollution and stillbirth: a population-based case-control study in Taiwan.
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DOI：
10.1289/ehp.1003056
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发表时间：
2011-09
影响因子：
10.4
通讯作者：
Jaakkola JJ
中科院分区：
文献类型：
--
作者：
Hwang BF;Lee YL;Jaakkola JJ
背景：有有限的证据表明，产前暴露于环境空气污染物可能会增加死胎的风险，但以前的流行病学研究并没有详细说明空气污染暴露对死胎影响的最易感妊娠期。目的：我们估计暴露于环境空气污染物和死产之间的关系，特别参考了胎儿最易受影响的妊娠期的评估。方法：我们在台湾进行了一项以人群为基础的病例对照研究。病例组为9325例死产，对照组为93250例死产，随机抽取台湾省2001-2007年1510064例单胎新生儿。采用调整后的logistic回归模型估算不同妊娠期和足月或早产（< 37周）出生状态下臭氧和二氧化氮每10-ppb变化的比值比（ORs），二氧化硫（SO2）每1-ppb变化的比值比（ORs），空气动力学直径≤10 μm颗粒物（PM10）每10-μg/m3变化的比值比（ORs），一氧化碳每100-ppb变化的比值比（ORs）。结果：死产增加与妊娠早期SO2增加1 ppb相关[校正OR = 1.02；95%可信区间（CI）， 1.00-1.04)，尤其是早产儿（调整后OR = 1.04; 95% CI, 1.01-1.07）。在妊娠第一个月（校正OR = 1.02; 95% CI, 1.00-1.05）和第二个月（校正OR = 1.02; 95% CI, 1.00-1.04），死产也与PM10增加10-μg/m3有关，并且，与二氧化硫一样，这种关联似乎仅限于早产（妊娠早期校正OR = 1.03; 95% CI, 1.00-1.07）。结论：该研究提供的证据表明，暴露于室外空气中SO2和PM10可能会增加死产的风险，特别是在早产儿中，并且最容易暴露的时间段是妊娠的前三个月。
Background: There is limited evidence suggesting that prenatal exposure to ambient air pollutants may increase the risk of stillbirth, but previous epidemiological studies have not elaborated the most susceptible gestational period for the effects of air pollution exposure on stillbirth. Objectives: We estimated associations between exposure to ambient air pollutants and stillbirth, with special reference to the assessment of gestational periods when the fetus is most susceptible. Methods: We conducted a population-based case–control study in Taiwan. The case group consisted of 9,325 stillbirths, and the control group included 93,250 births randomly selected from 1,510,064 Taiwanese singleton newborns in 2001–2007. Adjusted logistic regression models were used to estimate odds ratios (ORs) per 10-ppb change for ozone and nitrogen dioxide, 1-ppb change for sulfur dioxide (SO2), 10-μg/m3 change for particulate matter with aerodynamic diameter ≤ 10 μm (PM10), and 100-ppb change for carbon monoxide during different gestational periods and according to term or preterm (< 37 weeks) birth status. Results: Stillbirth increased in association with a 1-ppb increase in first-trimester SO2 [adjusted OR = 1.02; 95% confidence interval (CI), 1.00–1.04], particularly among preterm births (adjusted OR = 1.04; 95% CI, 1.01–1.07). Stillbirth was also associated with a 10-μg/m3 increase in PM10 during the first (adjusted OR = 1.02; 95% CI, 1.00–1.05) and second (adjusted OR = 1.02; 95% CI, 1.00–1.04) month of gestation, and, as with SO2, associations appeared to be restricted to preterm births (first-trimester adjusted OR = 1.03; 95% CI, 1.00–1.07). Conclusion: The study provides evidence that exposure to outdoor air SO2 and PM10 may increase the risk of stillbirth, especially among preterm births, and that the most susceptible time periods for exposure are during the first trimester of gestation.
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影响因子：
10.4
作者：
Hwang BF;Jaakkola JJ
通讯作者：
Jaakkola JJ
DOI：
10.1111/j.1753-6405.2008.00188.x
发表时间：
2008-04-01
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作者：
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作者：
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作者：
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通讯作者：
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影响因子：
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