Neck circumference, along with other anthropometric indices, has an independent and additional contribution in predicting fatty liver disease.
Neck circumference, along with other anthropometric indices, has an independent and additional contribution in predicting fatty liver disease.
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颈围与其他人体测量指标一起，在预测脂肪肝疾病方面具有独立且额外的贡献。
DOI：
10.1371/journal.pone.0118071
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Zhu HL
中科院分区：
文献类型：
--
作者：
Huang BX;Zhu MF;Wu T;Zhou JY;Liu Y;Chen XL;Zhou RF;Wang LJ;Chen YM;Zhu HL
先前的研究表明，颈围是肥胖和代谢综合征的重要预测指标，但对于脂肪肝疾病的证据却很少。我们研究了颈围与脂肪肝疾病的关联，并评估了其对中国成年人的预测价值。这项横断面研究包括 2009 年 5 月至 2010 年 4 月从中国广州健康体检中心招募的 4053 名参与者（1617 名女性和 2436 名男性，年龄 20-88 岁）。进行了人体测量、腹部超声检查并测量了血液生化参数。采用协方差、逻辑回归和受试者工作特征曲线分析。调整年龄后，无论女性还是男性，患有脂肪肝疾病的受试者的平均颈围均大于未患脂肪肝疾病的受试者（P<0.001）。 Logistic回归分析显示，颈围第4四分位数（与第1四分位数）脂肪肝疾病的年龄调整OR（95% CI）女性为7.70（4.95-11.99），男性为12.42（9.22-16.74）。在进一步调整其他人体测量指数（单独和组合）后，相应的 OR 仍然显着（所有 P 趋势<0.05），但女性衰减至 1.94-2.53，男性衰减至 1.45-2.08。颈围与其他人体测量指标之间存在相加交互作用（均 P<0.05）。对于BMI、腰围和腰臀比值较高和正常的参与者来说，高颈围值与脂肪肝患病率更高有关。颈围是脂肪肝疾病的独立预测因子，与其他人体测量指标一起应用时可提供额外的贡献。
Previous studies have indicated that neck circumference is a valuable predictor for obesity and metabolic syndrome, but little evidence is available for fatty liver disease. We examined the association of neck circumference with fatty liver disease and evaluated its predictive value in Chinese adults. This cross-sectional study comprised 4053 participants (1617 women and 2436 men, aged 20-88) recruited from the Health Examination Center in Guangzhou, China between May 2009 and April 2010. Anthropometric measurements were taken, abdominal ultrasonography was conducted and blood biochemical parameters were measured. Covariance, logistic regression and receiver operating characteristic curve analyses were employed. The mean neck circumference was greater in subjects with fatty liver disease than those without the disease in both women and men after adjusting for age (P<0.001). Logistic regression analysis showed that the age-adjusted ORs (95% CI) of fatty liver disease for quartile 4 (vs. quartile 1) of neck circumference were 7.70 (4.95-11.99) for women and 12.42 (9.22-16.74) for men. After further adjusting for other anthropometric indices, both individually and combined, the corresponding ORs remained significant (all P-trends<0.05) but were attenuated to 1.94-2.53 for women and 1.45-2.08 for men. An additive interaction existed between neck circumference and the other anthropometric measures (all P<0.05). A high neck circumference value was associated with a much greater prevalence of fatty liver disease in participants with both high and normal BMI, waist circumference and waist-to-hip ratio values. Neck circumference was an independent predictor for fatty liver disease and provided an additional contribution when applied with other anthropometric measures.
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