Visual Cues Predictive of Behaviorally Neutral Outcomes Evoke Persistent but Not Interval Timing Activity in V1, Whereas Aversive Conditioning Suppresses This Activity.
Visual Cues Predictive of Behaviorally Neutral Outcomes Evoke Persistent but Not Interval Timing Activity in V1, Whereas Aversive Conditioning Suppresses This Activity.
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预测行为中性结果的视觉线索会在 V1 中诱发持续而非间隔定时活动，而厌恶性条件反射会抑制这种活动。
DOI：
10.3389/fnsys.2021.611744
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发表时间：
2021
影响因子：
3
通讯作者：
Hussain Shuler MG
中科院分区：
文献类型：
--
作者：
Monk KJ;Allard S;Hussain Shuler MG
线索诱发的持续性活动是一种神经活动，这种神经活动在感觉线索的刺激之外持续存在，在大脑的许多区域，包括初级感觉区域都有描述。尽管如此，持续活动在主要感觉区域所起的功能作用仍然是个谜。然而，主要感觉区域持续活动的一种形式是视觉刺激和水奖励之间的时间表征。这种“奖励计时活动”——在初级视觉皮层中观察到——被认为与视觉提示和寻求奖励的行为的计时有关。尽管奖励结果足以在V1内产生间隔计时活动，但目前尚不清楚线索诱发的持续活动在奖励条件反射之外存在到何种程度，以及与其他结果（如行为中性或厌恶结果）的时间关系是否能够产生计时活动。在这里，我们描述了线索诱发的持续活动在小鼠V1中存在的三种条件反射策略：伪条件反射（将未配对的单眼视觉刺激反复呈现给动物），中性条件反射（将单眼视觉刺激与双眼视觉刺激配对，延迟）和厌恶条件反射（将单眼视觉刺激与尾部电击配对，延迟）。我们发现这些条件反射策略表现出三种形式之一的持续性活动：活动持续增加；活动减少：活动的持续减少；或者是一个延迟的，短暂的活动高峰，就像之前观察到的延迟奖励条件反射。然而，这些条件反射策略不会导致视觉提示的间隔时间活动，正如食欲条件反射后观察到的那样。此外，我们发现中性条件反射增加了线索诱发反应的强度，而厌恶条件反射强烈地降低了线索诱发的持续活动的强度和普遍性。这些结果表明，线索诱发的V1内持续活动可以存在于条件反射视觉刺激之外，具有延迟结果，并且这种持续活动可以通过不同的条件反射策略使用不同行为相关性的非条件刺激进行独特的调节。总之，这些数据扩展了我们对线索诱发的初级感觉皮层网络持续活动的理解，以及它被显著结果调节的能力。
Cue-evoked persistent activity is neural activity that persists beyond stimulation of a sensory cue and has been described in many regions of the brain, including primary sensory areas. Nonetheless, the functional role that persistent activity plays in primary sensory areas is enigmatic. However, one form of persistent activity in a primary sensory area is the representation of time between a visual stimulus and a water reward. This “reward timing activity”—observed within the primary visual cortex—has been implicated in informing the timing of visually cued, reward-seeking actions. Although rewarding outcomes are sufficient to engender interval timing activity within V1, it is unclear to what extent cue-evoked persistent activity exists outside of reward conditioning, and whether temporal relationships to other outcomes (such as behaviorally neutral or aversive outcomes) are able to engender timing activity. Here we describe the existence of cue-evoked persistent activity in mouse V1 following three conditioning strategies: pseudo-conditioning (where unpaired, monocular visual stimuli are repeatedly presented to an animal), neutral conditioning (where monocular visual stimuli are paired with a binocular visual stimulus, at a delay), and aversive conditioning (where monocular visual stimuli are paired with a tail shock, at a delay). We find that these conditioning strategies exhibit persistent activity that takes one of three forms, a sustained increase of activity; a sustained decrease of activity; or a delayed, transient peak of activity, as previously observed following conditioning with delayed reward. However, these conditioning strategies do not result in visually cued interval timing activity, as observed following appetitive conditioning. Moreover, we find that neutral conditioning increases the magnitude of cue-evoked responses whereas aversive conditioning strongly diminished both the response magnitude and the prevalence of cue-evoked persistent activity. These results demonstrate that cue-evoked persistent activity within V1 can exist outside of conditioning visual stimuli with delayed outcomes and that this persistent activity can be uniquely modulated across different conditioning strategies using unconditioned stimuli of varying behavioral relevance. Together, these data extend our understanding of cue-evoked persistent activity within a primary sensory cortical network and its ability to be modulated by salient outcomes.
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影响因子：
16.2
作者：
Guo W;Robert B;Polley DB
通讯作者：
Polley DB
影响因子：
9.8
作者：
Funayama K;Minamisawa G;Matsumoto N;Ban H;Chan AW;Matsuki N;Murphy TH;Ikegaya Y
通讯作者：
Ikegaya Y
视觉皮层的时间及其研究。
影响因子：
5
作者：
Shuler MG
通讯作者：
Shuler MG
DOI：
10.1101/lm.034355.114
发表时间：
2014-10
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Gavornik JP;Bear MF
通讯作者：
Bear MF
DOI：
10.1016/s0091-6773(76)91587-x
发表时间：
1976-01-01
期刊：
BEHAVIORAL BIOLOGY
影响因子：
--
作者：
BIGLER, ED;FLEMING, DE;SHEARER, DE
通讯作者：
SHEARER, DE