In Utero Ultrafine Particulate Exposure Yields Sex- and Dose-Specific Responses to Neonatal Respiratory Syncytial Virus Infection.
In Utero Ultrafine Particulate Exposure Yields Sex- and Dose-Specific Responses to Neonatal Respiratory Syncytial Virus Infection.
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子宫内超细颗粒暴露会对新生儿呼吸道合胞病毒感染产生性别和剂量特异性反应。
DOI：
10.1021/acs.est.2c02786
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发表时间：
2022-08-16
影响因子：
11.4
通讯作者：
Johnson, Natalie M.
中科院分区：
文献类型：
--
作者：
Lau, Carmen;Behlen, Jonathan C.;Myers, Alexandra;Li, Yixin;Zhao, Jiayun;Harvey, Navada;Wright, Gus;Hoffmann, Aline Rodrigues;Zhang, Renyi;Johnson, Natalie M.
关键词：
接触颗粒物(PM)与下呼吸道感染有关。超细颗粒(≤，UFP，0.1μm)在呼吸系统疾病中的作用尚未完全阐明，特别是在免疫未成熟人群的模型中。为了研究母体超微粒子暴露对新生儿感染的影响，我们将时间交配的C57BL/6n小鼠暴露在低剂量(LD，∼55μg/m~3)和高剂量(HD，∼275μg/m~3)的过滤空气或UFP中。在5天大的时候，后代被感染了一种呼吸道合胞病毒(RSV)毒株，这种病毒株与婴儿感染或假对照组相似。LD RSV组的后代体重因感染而显著减轻，尤其是雌性。肺基因表达分析显示，在假感染和RSV感染组中，暴露于HD的雄性后代中氧化应激和炎症相关基因的水平显著增加。在男性中，HD RSV组的炎症程度最高，而在女性中，LD RSV组的炎症程度最明显。总体而言，研究结果强调了新生儿的反应取决于后代的性别和母亲的UFP剂量。重要的是，婴儿呼吸道合胞病毒的病理可能会在即使是低剂量的UFP暴露后得到加强，这意味着防止母亲暴露的重要性。产前暴露于超细颗粒物会改变新生儿对呼吸道合胞病毒的反应，突出了环境政策保护儿童健康的必要性。
Exposure to particulate matter (PM) is associated with lower respiratory tract infections. The role of ultrafine particles (UFPs, ≤0.1 μm) in respiratory disease is not fully elucidated, especially in models of immunologically immature populations. To characterize the effects of maternal UFP exposure on neonatal infection, we exposed time-mated C57Bl/6n mice to filtered air or UFPs at a low dose (LD, ∼55 μg/m3) and high dose (HD, ∼275 μg/m3) throughout gestation. At 5 days of age, offspring were infected with a respiratory syncytial virus (RSV) strain known to mimic infant infection or sham control. Offspring body weights were significantly reduced in response to infection in the LD RSV group, particularly females. Pulmonary gene expression analysis demonstrated significantly increased levels of oxidative stress- and inflammation-related genes in HD-exposed male offspring in sham and RSV-infected groups. In males, the highest grade of inflammation was observed in the HD RSV group, whereas in females, the LD RSV group showed the most marked inflammation. Overall, findings highlight neonatal responses are dependent on offspring sex and maternal UFP dose. Importantly, infant RSV pathology may be enhanced following even low dose UFP exposure signifying the importance of preventing maternal exposure. Prenatal exposure to ultrafine PM alters neonatal responses to RSV highlighting the need for environmental policies to protect children’s health.
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空气颗粒物污染会导致婴儿死亡吗？系统回顾。
影响因子：
10.4
作者：
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通讯作者：
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影响因子：
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DOI：
10.1186/1476-069x-9-46
发表时间：
2010-08-02
期刊：
Environmental health : a global access science source
影响因子：
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作者：
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影响因子：
10
作者：
Morales-Rubio, Russell A.;Alvarado-Cruz, Isabel;De Vizcaya-Ruiz, Andrea
通讯作者：
De Vizcaya-Ruiz, Andrea
影响因子：
5.4
作者：
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通讯作者：
Durbin, JE