Air pollution and stillbirth risk: exposure to airborne particulate matter during pregnancy is associated with fetal death.
Air pollution and stillbirth risk: exposure to airborne particulate matter during pregnancy is associated with fetal death.
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DOI：
10.1371/journal.pone.0120594
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Muglia L
中科院分区：
文献类型：
--
作者：
DeFranco E;Hall E;Hossain M;Chen A;Haynes EN;Jones D;Ren S;Lu L;Muglia L
检验暴露于细颗粒物空气污染（PM2.5）与死产相关的假设。使用俄亥俄州出生记录（2006-2010年）和当地PM2.5测量值的基于地理空间的人群队列研究，由EPA（2005-2010年）通过俄亥俄州的57个监测站记录。每次分娩的母亲住所的地理坐标与最近的PM2.5监测站相关联，并计算每月暴露平均值。死产和PM2.5水平升高之间的关联进行了估计，调整了母亲的年龄，种族，教育水平，产前护理的数量，吸烟和受孕季节。研究期间，在俄亥俄州监测站居住≤10 km的非异常单胎（20-42周）中，有349，188例活产和1，848例死胎。俄亥俄州的平均PM2.5水平为13.3 μg/m3 [±1.8 SD，IQR（Q1：12.1，Q3：14.4，IQR：2.3）]，高于现行EPA标准12 μg/m3。妊娠期平均PM2.5暴露水平高与死产风险显著增加无关，adjOR为1.21（95%CI 0.96，1.53），妊娠早期或妊娠中期暴露水平高也不会增加死产风险。然而，在妊娠晚期暴露于高浓度的PM2.5与死产风险增加42%相关，adjOR 1.42（1.06，1.91）。妊娠晚期暴露于高水平的细颗粒物空气污染与死产风险增加有关。虽然与高PM2.5水平相关的风险增加是适度的，但对整体死胎率的潜在影响可能是强大的，因为所有孕妇都有潜在的风险。
To test the hypothesis that exposure to fine particulate air pollution (PM2.5) is associated with stillbirth. Geo-spatial population-based cohort study using Ohio birth records (2006-2010) and local measures of PM2.5, recorded by the EPA (2005-2010) via 57 monitoring stations across Ohio. Geographic coordinates of the mother’s residence for each birth were linked to the nearest PM2.5 monitoring station and monthly exposure averages calculated. The association between stillbirth and increased PM2.5 levels was estimated, with adjustment for maternal age, race, education level, quantity of prenatal care, smoking, and season of conception. There were 349,188 live births and 1,848 stillbirths of non-anomalous singletons (20-42 weeks) with residence ≤10 km of a monitor station in Ohio during the study period. The mean PM2.5 level in Ohio was 13.3 μg/m3 [±1.8 SD, IQR(Q1: 12.1, Q3: 14.4, IQR: 2.3)], higher than the current EPA standard of 12 μg/m3. High average PM2.5 exposure through pregnancy was not associated with a significant increase in stillbirth risk, adjOR 1.21(95% CI 0.96,1.53), nor was it increased with high exposure in the 1st or 2nd trimester. However, exposure to high levels of PM2.5 in the third trimester of pregnancy was associated with 42% increased stillbirth risk, adjOR 1.42(1.06,1.91). Exposure to high levels of fine particulate air pollution in the third trimester of pregnancy is associated with increased stillbirth risk. Although the risk increase associated with high PM2.5 levels is modest, the potential impact on overall stillbirth rates could be robust as all pregnant women are potentially at risk.
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DOI：
10.1186/1476-069x-11-40
发表时间：
2012-06-18
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Kloog I;Melly SJ;Ridgway WL;Coull BA;Schwartz J
通讯作者：
Schwartz J
影响因子：
5
作者：
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通讯作者：
Rich, David Q.
DOI：
10.1097/jom.0b013e31828df013
发表时间：
2013-05-01
影响因子：
3.2
作者：
Mainolfi, Maria B.;Salihu, Hamisu M.;Mbah, Alfred K.
通讯作者：
Mbah, Alfred K.
影响因子：
3.5
作者：
Vassilev, ZP;Robson, MG;Klotz, JB
通讯作者：
Klotz, JB
影响因子：
10.4
作者：
Hwang BF;Lee YL;Jaakkola JJ
通讯作者：
Jaakkola JJ