Increased prefrontal cortex activity during negative emotion regulation as a predictor of depression symptom severity trajectory over 6 months.
Increased prefrontal cortex activity during negative emotion regulation as a predictor of depression symptom severity trajectory over 6 months.
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负面情绪调节期间额叶皮层活性增加，这是6个月内抑郁症状严重程度轨迹的预测指标。
DOI：
10.1001/jamapsychiatry.2013.2430
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发表时间：
2013-11
期刊：
影响因子：
25.8
通讯作者：
Davidson, Richard J.
中科院分区：
文献类型：
--
作者：
Heller, Aaron S.;Johnstone, Tom;Peterson, Michael J.;Kolden, Gregory G.;Kalin, Ned H.;Davidson, Richard J.
情绪调节在抑郁症中受到严重破坏，利用这些过程的范例可能会发现治疗期间神经生物学的基本变化。此外，由于抑郁症的神经影像学结局研究通常只使用基线和终点数据-这在神经病学中更容易产生周与周之间的噪音-我们试图在六个月的试验过程中使用所有数据点。检查成功治疗后神经生物学的变化。双盲试验，检查在六个月的试验中，两种抗抑郁药治疗之一引起的涉及情绪调节的神经回路的变化。参与者在治疗前、治疗后2个月和6个月进行扫描。大学功能磁共振成像设备。21例重度抑郁症患者，无其他轴I或轴II诊断。文拉法辛XR（剂量高达300 mg）或氟西汀（剂量高达80 mg）。神经活动，在执行情绪调节范式期间使用功能性磁共振成像测量，以及通过汉密尔顿抑郁症评定量表定期评估症状严重程度。为了利用所有数据点，计算了抑郁严重程度的变化率以及神经参与的变化率的斜率轨迹。在6个月内抑郁严重程度下降最快的抑郁个体，在同一时间段内调节负面情绪时，BA 10和右侧DLPFC活性增加最快。这种关系比仅使用基线和终点数据时更稳健。调节负面情绪时PFC参与的变化与6个月内抑郁严重程度的变化相关。通过计算这些统计数据来支持这些结果，这些统计数据比差异评分对周间变化更可靠和稳健。
Emotion regulation is critically disrupted in depression and use of paradigms tapping these processes may uncover essential changes in neurobiology during treatment. In addition, as neuroimaging outcome studies of depression commonly utilize solely baseline and endpoint data – which is more prone to week-to week noise in symptomatology – we sought to use all data points over the course of a six month trial. To examine changes in neurobiology resulting from successful treatment. Double-blind trial examining changes in the neural circuits involved in emotion regulation resulting from one of two antidepressant treatments over a six month trial. Participants were scanned pretreatment, at 2 months and 6 months posttreatment. University functional magnetic resonance imaging facility. 21 patients with Major Depressive Disorder and without other Axis I or Axis II diagnoses. Venlafaxine XR (doses up to 300mg) or Fluoxetine (doses up to 80mg). Neural activity, as measured using functional magnetic resonance imaging during performance of an emotion regulation paradigm as well as regular assessments of symptom severity by the Hamilton Rating Scale for Depression. To utilize all data points, slope trajectories were calculated for rate of change in depression severity as well as rate of change of neural engagement. Those depressed individuals showing the steepest decrease in depression severity over the six months were those individuals showing the most rapid increases in BA10 and right DLPFC activity when regulating negative affect over the same time frame. This relationship was more robust than when using solely the baseline and endpoint data. Changes in PFC engagement when regulating negative affect correlate with changes in depression severity over six months. These results are buttressed by calculating these statistics which are more reliable and robust to week-to-week variation than difference scores.
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DOI：
10.1176/appi.ajp.2012.12010014
发表时间：
2013-02
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Heller AS;Johnstone T;Light SN;Peterson MJ;Kolden GG;Kalin NH;Davidson RJ
通讯作者：
Davidson RJ
影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
DOI：
10.1192/bjp.bp.108.056093
发表时间：
2009-06
期刊：
The British journal of psychiatry : the journal of mental science
影响因子：
--
作者：
Murphy SE;Norbury R;O'Sullivan U;Cowen PJ;Harmer CJ
通讯作者：
Harmer CJ
影响因子：
6.6
作者：
Delaveau, Pauline;Jabourian, Maritza;Fossati, Philippe
通讯作者：
Fossati, Philippe
影响因子：
5.7
作者：
Hariri, AR;Tessitore, A;Weinberger, DR
通讯作者：
Weinberger, DR