Relationships between changes in sustained fronto-striatal connectivity and positive affect in major depression resulting from antidepressant treatment.
Relationships between changes in sustained fronto-striatal connectivity and positive affect in major depression resulting from antidepressant treatment.
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DOI：
10.1176/appi.ajp.2012.12010014
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Davidson RJ
中科院分区：
文献类型：
--
作者：
Heller AS;Johnstone T;Light SN;Peterson MJ;Kolden GG;Kalin NH;Davidson RJ
积极情感及其神经基础的缺陷与重度抑郁症有关。然而，积极影响的减少是否仅仅是由于伏隔核活动和额纹状体连接性的整体减少造成的，还是由于该网络随着时间的推移而无法维持参与的额外原因尚不清楚。因此，我们试图确定治疗引起的在积极情绪调节过程中维持伏隔核活动和额纹状体连接能力的变化是否与积极情绪的增益相关。使用功能磁共振成像，我们评估了 21 名抑郁症患者在接受抗抑郁治疗之前和之后 2 个月后，在执行情绪调节范式期间尝试增加积极情绪时维持奖励相关网络活动的能力。在相同的时间间隔内对 14 名健康对照受试者进行了扫描。治疗两个月后，自我报告的积极情绪有所增加。两个月内伏隔核持续活动增加最多的患者是积极情绪增加最多的患者。此外，那些表现出持续额纹状体连接增加最大的患者也是那些在控制消极情绪时表现出积极情绪增加最大的患者。健康对照没有显示出这些关联。治疗引起的额纹状体回路持续参与的变化追踪日常生活中积极情绪的体验。当试图了解日常积极情绪的变化时，检查各种精神疾病中积极情绪减少的研究可能会受益于检查大脑活动的时间动态。
Deficits in positive affect and their neural bases have been associated with major depression. However, whether reductions in positive affect result solely from an overall reduction in nucleus accumbens activity and fronto-striatal connectivity or the additional inability to sustain engagement over time of this network is unknown. Accordingly, we sought to determine whether treatment-induced changes in the ability to sustain nucleus accumbens activity and fronto-striatal connectivity during the regulation of positive affect are associated with gains in positive affect. Using fMRI, we assessed the ability to sustain activity in reward-related networks when attempting to increase positive emotion during performance of an emotion regulation paradigm in 21 depressed patients prior to, and after 2 months of antidepressant treatment. 14 healthy control subjects were scanned over the same interval. After 2 months of treatment, self-reported positive affect increased. Those patients demonstrating the largest increases in sustained nucleus accumbens activity over the 2 months were those demonstrating the largest increases in positive affect. In addition, those patients demonstrating the largest increases in sustained fronto-striatal connectivity were also those demonstrating the largest increases in positive affect when controlling for negative affect. Healthy controls showed none of these associations. Treatment induced changes in the sustained engagement of fronto-striatal circuitry tracks the experience of positive emotion in daily life. Studies examining reduced positive affect in a variety of psychiatric disorders might benefit from examining the temporal dynamics of brain activity when attempting to understand changes in daily positive affect.
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DOI：
10.1176/appi.ajp.2008.08081201
发表时间：
2009-06
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Pizzagalli DA;Holmes AJ;Dillon DG;Goetz EL;Birk JL;Bogdan R;Dougherty DD;Iosifescu DV;Rauch SL;Fava M
通讯作者：
Fava M
影响因子：
3.7
作者：
Dichter, GS;Tomarken, AJ;Sutton, SK
通讯作者：
Sutton, SK
影响因子：
34.7
作者：
DeRubeis, Robert J.;Siegle, Greg J.;Hollon, Steven D.
通讯作者：
Hollon, Steven D.
影响因子：
11
作者：
Harvey, P-O;Pruessner, J.;Lepage, M.
通讯作者：
Lepage, M.
DOI：
10.1073/pnas.0910651106
发表时间：
2009-12-29
影响因子：
11.1
作者：
Heller, Aaron S.;Johnstone, Tom;Davidson, Richard J.
通讯作者：
Davidson, Richard J.