Application of QCM in Peptide and Protein-Based Drug Product Development.
Application of QCM in Peptide and Protein-Based Drug Product Development.
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DOI：
10.3390/molecules25173950
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发表时间：
2020-08-29
期刊：
影响因子：
--
通讯作者：
Suchy D
中科院分区：
文献类型：
--
作者：
Migoń D;Wasilewski T;Suchy D
AT切割石英晶体以厚度剪切模式（TSM）振动，特别是石英晶体谐振器（QCR），由于其灵敏度、准确度和生物功能化能力而被称为非常有效的质量敏感系统。它们在测量气体和液体基质中沉积样品的质量方面具有高度可靠性。此外，它们提供实时监控，以及相对较低的生产和运营成本。这些特性使质量敏感系统适用于广泛的不同应用，包括蛋白质和肽的初级包装，配方和药品生产工艺开发的研究。本文综述了石英晶体微天平（QCM）仪器在蛋白质和肽类药物开发中的应用及其前景。
AT-cut quartz crystals vibrating in the thickness-shear mode (TSM), especially quartz crystal resonators (QCRs), are well known as very efficient mass sensitive systems because of their sensitivity, accuracy, and biofunctionalization capacity. They are highly reliable in the measurement of the mass of deposited samples, in both gas and liquid matrices. Moreover, they offer real-time monitoring, as well as relatively low production and operation costs. These features make mass sensitive systems applicable in a wide range of different applications, including studies on protein and peptide primary packaging, formulation, and drug product manufacturing process development. This review summarizes the information on some particular implementations of quartz crystal microbalance (QCM) instruments in protein and peptide drug product development as well as their future prospects.
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影响因子：
3.1
作者：
Atay, Seda;Piskin, Kevser;Denizli, Adil
通讯作者：
Denizli, Adil
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1
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7.8
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通讯作者：
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