Recovery of motor and cognitive function after cerebellar lesions in a songbird: role of estrogens.
Recovery of motor and cognitive function after cerebellar lesions in a songbird: role of estrogens.
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DOI：
10.1111/j.1460-9568.2009.06685.x
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Day LB
中科院分区：
文献类型：
--
作者：
Spence RD;Zhen Y;White S;Schlinger BA;Day LB
除了在复杂运动功能中发挥关键作用外，人们越来越认识到小脑在认知中也发挥着重要作用。鸣禽是研究运动和认知过程的特别好的模型，但人们对鸣禽小脑在这些过程中的作用知之甚少。为了探索鸣禽的小脑功能，我们对成年雌性斑胸草雀的小脑进行了损伤，并检查了其对空间工作记忆任务和该任务期间运动功能的影响。有证据表明鸣禽大脑中存在类固醇合成，神经类固醇可能对成年鸣禽的某些形式的神经可塑性产生影响。因此，我们假设神经类固醇会影响小脑损伤后的运动和认知功能。我们发现小脑病变会导致空间任务的运动和认知方面的缺陷。与我们的预测一致，与雌激素合成受阻但雌激素替代的鸟类相比，雌激素合成受阻的鸟类在我们的空间任务中的表现受损。雌激素替代对运动功能没有明显影响。我们还发现，病变诱导小脑病变周围的反应性星形胶质细胞和伯格曼胶质细胞中雌激素合成酶芳香酶的表达。这些数据表明鸣禽的小脑介导运动和认知功能，并且雌激素可以改善损伤后小脑功能认知方面的恢复。
In addition to its key role in complex motor function, the cerebellum is increasingly recognized to have a role in cognition. Songbirds are particularly good models for the investigation of motor and cognitive processes but little is known about the role of the songbird cerebellum in these processes. To explore cerebellar function in a songbird, we lesioned the cerebellum of adult female zebra finches and examined the effects on a spatial working memory task and on motor function during this task. There is evidence for steroid synthesis in the songbird brain and neurosteroids may have an impact on some forms of neural plasticity in adult songbirds. We therefore hypothesized that neurosteroids would affect motor and cognitive function after a cerebellar injury. We found that cerebellar lesions produced deficits in motor and cognitive aspects of a spatial task. In line with our prediction, birds in which estrogen synthesis was blocked had impaired performance in our spatial task compared with those that had estrogen synthesis blocked but estrogen replaced. There was no clear effect of estrogen replacement on motor function. We also found that lesions induced expression of the estrogen synthetic enzyme aromatase in reactive astrocytes and Bergmann glia around a cerebellar lesion. These data suggest that the cerebellum of songbirds mediates both motor and cognitive function and that estrogens may improve the recovery of cognitive aspects of cerebellar function after injury.
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DOI：
10.1016/0960-0760(90)90490-c
发表时间：
1990-11-20
影响因子：
4.1
作者：
BAULIEU, EE;ROBEL, P
通讯作者：
ROBEL, P
影响因子：
4.9
作者：
Ghidoni, R.;Boccardi, M.;Binetti, G.
通讯作者：
Binetti, G.
影响因子：
5.3
作者：
Andreescu, Corina E.;Milojkovic, Bogdan A.;De Jeu, Marcel T. G.
通讯作者：
De Jeu, Marcel T. G.
影响因子：
3.4
作者：
Nixon, PD;Passingham, RE
通讯作者：
Passingham, RE
影响因子：
2.5
作者：
London, SE;Boulter, J;Schlinger, BA
通讯作者：
Schlinger, BA