NB-LRR proteins: pairs, pieces, perception, partners, and pathways.

NB-LRR proteins: pairs, pieces, perception, partners, and pathways.
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DOI:
10.1016/j.pbi.2010.04.007
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发表时间:
2010-08
影响因子:
9.5
通讯作者:
Dangl JL
Dangl JL
中科院分区:
生物学2区
文献类型:
--
作者:
Eitas TK;Dangl JL

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在植物中,许多先天免疫受体或抗病(R)蛋白含有NB-LRR(核苷酸结合位点,富亮氨酸重复序列)结构。本文总结了有关NB-LRR信号传导的最新发现。一个新出现的主题是,两个nb - lrr可以一起起作用,介导对病原体分离物的疾病抗性。此外,最近的研究结果描述了哪些NB-LRR蛋白片段足以启动防御信号。重要的是,不同nb - lrr的不同片段足以发挥功能。最后,我们描述了辅助蛋白和下游宿主基因在NB-LRR信号传导中的新作用。
In plants, many of the innate immune receptors or disease resistance (R) proteins contain a NB-LRR (Nucleotide-binding site, Leucine-rich repeat) structure. The recent findings regarding NB-LRR signaling are summarized in this article. An emerging theme is that two NB-LRRs can function together to mediate disease resistance against pathogen isolates. Also, recent results delineate which NB-LRR protein fragments are sufficient to initiate defense signaling. Importantly, distinct fragments of different NB-LRRs are sufficient for function. Finally, we describe the new roles of accessory proteins and downstream host genes in NB-LRR signaling.
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