NB-LRR proteins: pairs, pieces, perception, partners, and pathways.
NB-LRR proteins: pairs, pieces, perception, partners, and pathways.
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DOI:
10.1016/j.pbi.2010.04.007
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发表时间:
2010-08
影响因子:
9.5
通讯作者:
Dangl JL
中科院分区:
文献类型:
--
作者:
Eitas TK;Dangl JL
In plants, many of the innate immune receptors or disease resistance (R) proteins contain a NB-LRR (Nucleotide-binding site, Leucine-rich repeat) structure. The recent findings regarding NB-LRR signaling are summarized in this article. An emerging theme is that two NB-LRRs can function together to mediate disease resistance against pathogen isolates. Also, recent results delineate which NB-LRR protein fragments are sufficient to initiate defense signaling. Importantly, distinct fragments of different NB-LRRs are sufficient for function. Finally, we describe the new roles of accessory proteins and downstream host genes in NB-LRR signaling.
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