Post-transcriptional diversity in riboproteins and RNAs in aging and cancer.
Post-transcriptional diversity in riboproteins and RNAs in aging and cancer.
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DOI：
10.1016/j.semcancer.2021.08.012
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发表时间：
2021-11
影响因子：
14.5
通讯作者：
Lemos B
中科院分区：
文献类型：
--
作者：
Cruz J;Lemos B
核苷酸和氨基酸的转录后（PtscM）和翻译后（PtrnM）修饰是能够改变RNA和蛋白质的理化性质的共价修饰。在核糖体中，核糖体RNA和核糖体蛋白亚基在核仁中的充分组装确保了合适的翻译活性，蛋白质合成根据细胞内能量产生、复制、增殖和生长的需求进行调节。PtscM和PtrnM的调节控制的中断可以损害核糖体生物发生和核糖体功能。核糖体损伤可能反过来影响参与端粒维持、细胞凋亡和DNA修复等各种功能的蛋白质的合成，以及与线粒体和端粒酶活性交叉。这些细胞过程经常在癌变和衰老中发生故障。在这里，我们讨论PtscMs和PtrnMs对核糖体功能的调节机制。我们还讨论了rRNA的化学修饰及其对细胞代谢，复制控制和衰老的影响。此外，我们强调PtscMs和PtrnMs在衰老和癌变过程中的核糖体中间体的相似性和差异。了解这些调节机制可能会发现开发更有效的肿瘤和抗衰老疗法的关键步骤。
Post-transcriptional (PtscM) and post-translational (PtrnM) modifications of nucleotides and amino acids are covalent modifications able to change physio-chemical properties of RNAs and proteins. In the ribosome, the adequate assembly of rRNAs and ribosomal protein subunits in the nucleolus ensures suitable translational activity, with protein synthesis tuned according to intracellular demands of energy production, replication, proliferation, and growth. Disruption in the regulatory control of PtscM and PtrnM can impair ribosome biogenesis and ribosome function. Ribosomal impairment may, in turn, impact the synthesis of proteins engaged in functions as varied as telomere maintenance, apoptosis, and DNA repair, as well as intersect with mitochondria and telomerase activity. These cellular processes often malfunction in carcinogenesis and senescence. Here we discuss regulatory mechanisms of PtscMs and PtrnMs on ribosomal function. We also address chemical modification in rRNAs and their impacts on cellular metabolism, replication control, and senescence. Further, we highlight similarities and differences of PtscMs and PtrnMs in ribosomal intermediates during aging and carcinogenesis. Understanding these regulatory mechanisms may uncover critical steps for the development of more efficient oncologic and anti-aging therapies.
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影响因子：
3.6
作者：
Achi, MV;Ravindranath, N;Dym, M
通讯作者：
Dym, M
DOI：
10.1016/j.tig.2019.07.011
发表时间：
2019-10
期刊：
Trends in genetics : TIG
影响因子：
--
作者：
Cerqueira AV;Lemos B
通讯作者：
Lemos B
影响因子：
3
作者：
Berciano, Maria T.;Novell, Mariona;Lafarga, Miguel
通讯作者：
Lafarga, Miguel
影响因子：
--
作者：
Fancello L;Kampen KR;Hofman IJ;Verbeeck J;De Keersmaecker K
通讯作者：
De Keersmaecker K
影响因子：
2.4
作者：
Haneji T;Teramachi J;Hirashima K;Kimura K;Morimoto H
通讯作者：
Morimoto H