Sustained high levels of serum leptin rather than IL-6 observed in patients with postpartum thyroiditis during their first postpartum year
Sustained high levels of serum leptin rather than IL-6 observed in patients with postpartum thyroiditis during their first postpartum year
复制标题
产后甲状腺炎患者在产后第一年观察到持续高水平的血清瘦素而不是 IL-6
DOI：
10.1007/s12020-014-0176-3
复制
发表时间：
2014-02
期刊：
影响因子：
3.7
通讯作者：
Li Yushu
中科院分区：
文献类型：
--
作者：
Guan Haixia;Li Yushu
本研究旨在探讨产后第一年瘦素和白细胞介素-6（IL-6）在产后甲状腺炎（PPT）发生发展中的作用。我们回顾性收集了57例PPT患者的血清样本，其中包括34例显性PPT（O-PPT）和23例亚临床PPT（S-PPT），以及37例健康产后妇女在产后4个时间点的血清样本，即，3-产后3d、6、12个月。分别采用放射免疫法和ELISA法测定血清瘦素和IL-6水平。产后1年内，PPT组的瘦素水平和瘦素/BMI（LEP/BMI）比值均高于对照组，但O-PPT组和S-PPT组间差异无统计学意义。然而，在产后期间观察到PPT患者和对照妇女的IL-6水平的类似趋势，但没有达到显著差异。我们的结论是，持续高水平的血清瘦素分娩后可能参与产后抑郁症的发病机制。IL-6不参与PPT的发展。
The purpose of the study is to explore the roles of leptin and interleukin-6 (IL-6) during the first postpartum year in the occurrence and development of postpartum thyroiditis (PPT). We retrospectively collected serum samples from 57 PPT patients consisting of 34 overt PPT (O-PPT) and 23 subclinical PPT (S-PPT) in addition to 37 healthy postpartum women at four postpartum time points, i.e., 3-day and 3, 6, 12-month postpartum. Serum leptin and IL-6 levels were measured by radioimmunoassay and ELISA assay, respectively. Leptin level and leptin/BMI (LEP/BMI) ratio were higher in PPT patients than in control during the first postpartum year, but were not significantly different between O-PPT and S-PPT. However, a similar trend but did not reach significant difference in IL-6 level was observed during the postpartum period in PPT patients and control women. We conclude that a sustained high level of serum leptin after delivery may be involved in the pathogenesis of PPT. IL-6 does not contribute to the development of PPT.
登录
查看更多内容
影响因子：
64.8
作者：
Yiying Zhang;R. Proenca;M. Maffei;M. Barone;L. Leopold;J. Friedman
通讯作者：
Yiying Zhang;R. Proenca;M. Maffei;M. Barone;L. Leopold;J. Friedman
影响因子：
64.8
作者：
ZHANG, YY;PROENCA, R;FRIEDMAN, JM
通讯作者：
FRIEDMAN, JM
影响因子：
4
作者：
Leonhardt, U;Ritzel, U;Ramadori, G
通讯作者：
Ramadori, G
影响因子：
20.3
作者：
A. Muller;H. Drexhage;A. Berghout
通讯作者：
A. Muller;H. Drexhage;A. Berghout
DOI：
10.1089/thy.1998.8.1081
发表时间：
1998-12
期刊：
Thyroid : official journal of the American Thyroid Association
影响因子：
--
作者：
M. Diekman;J. Romijn;E. Endert;H. Sauerwein;W. Wiersinga
通讯作者：
M. Diekman;J. Romijn;E. Endert;H. Sauerwein;W. Wiersinga