Polypeptide - decorated nanoliposomes as novel delivery systems for lutein.
Polypeptide - decorated nanoliposomes as novel delivery systems for lutein.
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DOI：
10.1039/c8ra05838e
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发表时间：
2018-09-05
期刊：
影响因子：
3.9
通讯作者：
Xiao, Yadong
中科院分区：
文献类型：
--
作者：
Jiao, Yan;Li, Dajing;Liu, Chunquan;Chang, Ying;Song, Jiangfeng;Xiao, Yadong
叶黄素（LUT）是一种存在于各种蔬菜中的生物活性食品化合物，在促进健康和福祉方面起着至关重要的作用。然而，叶黄素是一种不稳定的分子，由于其在水介质中的溶解度较差，其生物利用度非常低，口服时吸收不良。为了提高叶黄素的稳定性、释放性和生物活性，研究开发了聚赖氨酸修饰纳米脂质体（PLL - lut - nlp）作为叶黄素的新型递送系统。PLL-LUT-NLP的平均粒径在264 ~ 367nm之间，多分散性指数较低（PDI < 0.4）。zeta电位从未修饰纳米脂质体的- 38.6 mV变化到pll修饰纳米脂质体的- 27.9 mV。此外，在0.06% (w/v) PLL修饰的纳米脂质体中，PLL - lut - nlp的叶黄素包封效率（EE%）最高。PLL可以保护纳米脂质体中的叶黄素不被降解，并促进胃肠道液体条件下纳米脂质体中叶黄素的释放。此外，经pll修饰的纳米脂质体保持了叶黄素的抗氧化活性，其抑制肿瘤细胞增殖的活性比未经修饰的纳米脂质体更显著。这些结果表明，pll修饰的纳米脂质体有潜力用于叶黄素的有效递送，并进一步提高其生物利用度。制备了多肽修饰的纳米脂质体，以提高叶黄素的稳定性、释放性和生物活性。
Lutein (LUT) is a bioactive food compound found in various vegetables and plays a critical role in the promotion of health and well-being. However, lutein is an unstable molecule which has a very low bioavailability caused by its poor solubility in aqueous media, and is poorly absorbed when administered orally. To enhance the stability, release and bioactivity of lutein, poly-l-lysine (PLL) decorated nanoliposomes (PLL–LUT-NLP) were developed as novel delivery systems for lutein. The mean particle size of PLL–LUT-NLP was found to be in the range 264–367 nm with a low polydispersity index (PDI < 0.4). The zeta potential changed from −38.6 mV in undecorated nanoliposomes to −27.9 mV in PLL-decorated nanoliposomes. Furthermore, the lutein entrapment efficiency (EE%) of PLL–LUT-NLP was found to be highest in nanoliposomes decorated with 0.06% (w/v) PLL. PLL could protect lutein in nanoliposomes from degradation and promote the lutein release from the nanoliposomes in gastrointestinal fluid conditions. Additionally, the PLL-decorated nanoliposomes maintained the antioxidant activity of the lutein, and the antiproliferative activity was more significant than that of undecorated nanoliposomes in inhibiting the proliferation of human tumor cells. These results suggest that PLL-decorated nanoliposomes have potential to be used for efficient delivery of lutein and further improve its bioavailability. Polypeptide decorated nanoliposomes were prepared as novel delivery systems to enhance the stability, release and bioactivity of lutein.
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