Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).
Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).
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DOI：
10.3390/ijerph18030963
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发表时间：
2021-01-22
影响因子：
--
通讯作者：
Tuells J
中科院分区：
文献类型：
--
作者：
Díez-Domingo J;Sánchez-Alonso V;Villanueva RJ;Acedo L;Tuells J
人类乳头瘤病毒(HPV)疫苗计划的一个主要挑战是普遍的性别中立建议，以及对其长期效果的估计。这项研究的目的是预测男性疫苗接种的额外好处，特别是在男男性行为者(MSM)中，并分析该计划对社会的影响。我们提出了基于网络范式的HPV感染的数学模型。来自西班牙的数据允许构造性网络。HPV感染力取自文献。对男性和女性使用不同疫苗覆盖率的不同情况进行了研究。在异性恋人群中表现出很强的群体免疫力，在14岁时只接种女性疫苗的男性和未接种疫苗的女性的HPV6/11感染显著减少。该方案对男男性接触者的感染率无影响。这一群体只会从包括男性在内的疫苗接种计划中受益。然而，在短期内，这种影响将低于异性恋男性。对男男性接触者的保护只能通过对男性直接接种疫苗来实现。这可能会对公共卫生产生重要影响。
A major challenge in human papillomavirus (HPV) vaccine programs is the universal gender-neutral recommendation, as well as estimation of its long-term effect. The objective of this study is to predict the added benefit of male vaccination, especially in men who have sex with men (MSM), and to analyze the impact of the program on society. We propose a mathematical model of the HPV infection based on a network paradigm. Data from Spain allowed constructing the sexual network. HPV force of infection was taken from literature. Different scenarios using variable vaccine coverage in both males and females were studied. Strong herd immunity is shown in the heterosexual population, with an important decrease of HPV 6/11 infections both in men and in unvaccinated women with an only-women vaccination at 14 years of age. No impact of this program occurred in the infection incidence in MSM. This group would only benefit from a vaccination program that includes males. However, the impact at short term would be lower than in heterosexual men. The protection of MSM can only be achieved by direct vaccination of males. This may have important consequences for public health.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
5.5
作者：
Choi, Yoon Hong;Jit, Mark;Edmunds, William John
通讯作者：
Edmunds, William John
影响因子：
3.8
作者：
Duncan, Katrina C.;Chan, Keith J.;Press, Natasha M.
通讯作者：
Press, Natasha M.
DOI：
10.1093/cid/ciw354
发表时间：
2016-08-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Garland SM;Kjaer SK;Muñoz N;Block SL;Brown DR;DiNubile MJ;Lindsay BR;Kuter BJ;Perez G;Dominiak-Felden G;Saah AJ;Drury R;Das R;Velicer C
通讯作者：
Velicer C
影响因子：
3.7
作者：
Burger, Emily A.;Sy, Stephen;Kim, Jane J.
通讯作者：
Kim, Jane J.