Radon and risk of extrapulmonary cancers: results of the German uranium miners' cohort study, 1960-2003.
Radon and risk of extrapulmonary cancers: results of the German uranium miners' cohort study, 1960-2003.
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DOI：
10.1038/sj.bjc.6604776
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发表时间：
2008-12-02
影响因子：
8.8
通讯作者：
Grosche, B.
中科院分区：
文献类型：
--
作者：
Kreuzer, M.;Walsh, L.;Schnelzer, M.;Tschense, A.;Grosche, B.
对德国矿工队列研究的数据进行了分析，以调查环境空气中的氡是否会导致肺癌以外的癌症。该队列包括58987名男性，他们从1946年到1989年在德国东部的前Wismut铀矿公司工作了至少6个月。在1960年至2003年的随访期间，共观察到20 684例死亡。将24个癌症部位的死亡率与年龄和日历年的全国死亡率进行了比较。内部泊松回归被用来估计超额相对危险度（ERR）单位累积接触氡在工作水平月（WLM）。观察到的肺外癌症合并死亡人数（O）接近全国死亡率的预期人数（E）（n=3340，O/E=1.02; 95%置信区间（CI）：0.98-1.05）。胃癌死亡率在统计上显着增加（O/E=1.15; 95% CI：1.06-1.25）和肝脏（O/E=1.26; 95%CI：1.07-1.48），而舌癌、口腔癌、唾液腺癌和咽癌的发病率则显著下降（O/E=0.80; 95%CI：0.65-0.97）和膀胱的那些（O/E=0.82; 95%CI：0.70-0.95）。观察到所有肺外癌与累积氡暴露的统计学显著关系（ERR/WLM=0.014%; 95%CI：0.006-0.023%）。大多数网站显示积极的风险-反应关系，但这些都是微不足道的或调整后的潜在混杂因素，如砷或粉尘暴露变得微不足道。目前的数据提供了一些证据表明，与氡有关的肺外癌的风险增加，但不能排除机会和混淆。
Data from the German miners' cohort study were analysed to investigate whether radon in ambient air causes cancers other than lung cancer. The cohort includes 58 987 men who were employed for at least 6 months from 1946 to 1989 at the former Wismut uranium mining company in Eastern Germany. A total of 20 684 deaths were observed in the follow-up period from 1960 to 2003. The death rates for 24 individual cancer sites were compared with the age and calendar year-specific national death rates. Internal Poisson regression was used to estimate the excess relative risk (ERR) per unit of cumulative exposure to radon in working level months (WLM). The number of deaths observed (O) for extrapulmonary cancers combined was close to that expected (E) from national rates (n=3340, O/E=1.02; 95% confidence interval (CI): 0.98–1.05). Statistically significant increases in mortality were recorded for cancers of the stomach (O/E=1.15; 95% CI: 1.06–1.25) and liver (O/E=1.26; 95% CI: 1.07–1.48), whereas significant decreases were found for cancers of the tongue, mouth, salivary gland and pharynx combined (O/E=0.80; 95% CI: 0.65–0.97) and those of the bladder (O/E=0.82; 95% CI: 0.70–0.95). A statistically significant relationship with cumulative radon exposure was observed for all extrapulmonary cancers (ERR/WLM=0.014%; 95% CI: 0.006–0.023%). Most sites showed positive exposure–response relationships, but these were insignificant or became insignificant after adjustment for potential confounders such as arsenic or dust exposure. The present data provide some evidence of increased risk of extrapulmonary cancers associated with radon, but chance and confounding cannot be ruled out.
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影响因子：
8.8
作者：
Grosche, B.;Kreuzer, M.;Tschense, A.
通讯作者：
Tschense, A.
影响因子：
2.2
作者：
Kreuzer, M;Brachner, A;Grosche, B
通讯作者：
Grosche, B
影响因子：
168.9
作者：
TOMASEK, L;DARBY, SC;KUNZ, E
通讯作者：
KUNZ, E
影响因子：
10.3
作者：
DARBY, SC;WHITLEY, E;YAO, SX
通讯作者：
YAO, SX
影响因子：
13.6
作者：
Laurier, D;Tirmarche, M;Quesne, B
通讯作者：
Quesne, B