Behavioral economic analysis of opioid consumption in heroin-dependent individuals: effects of alternative reinforcer magnitude and post-session drug supply.
Behavioral economic analysis of opioid consumption in heroin-dependent individuals: effects of alternative reinforcer magnitude and post-session drug supply.
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DOI：
10.1016/j.drugalcdep.2009.04.006
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发表时间：
2009-09-01
影响因子：
4.2
通讯作者：
Steinmiller, Caren L.
中科院分区：
文献类型：
--
作者：
Greenwald, Mark K.;Steinmiller, Caren L.
关键词：
本研究探讨了氢吗啡酮（HYD）的选择和行为经济需求的影响程度HYD单价（UP），替代货币加固幅度和会后HYD供应。接受丁丙诺啡8 mg/天稳定的海洛因依赖性研究志愿者（n=13）首先采样两个HYD剂量（12和24 mg IM，标记为药物A [疗程1]和药物B [疗程2]）。在最后六个阶段中的每一个阶段，志愿者都可以获得12次试验选择渐进比例（PR）任务，并可以获得HYD单位剂量（2 mg，固定）或金钱（2美元或4美元，在工作会议后立即管理）。在PR任务之前，志愿者被告知在接受PR视情况剂量后3小时将提供哪种HYD补充剂量（无，药物A或B）。当4美元相对于2美元同时可用时，PR-特遣队HYD选择显着减少。关于会后HYD补充剂的信息缓和了这种影响：当受试者被告知有补充剂量时，当金钱选择较小（2美元）时，寻求HYD的行为减少，但当金钱选择较高（4美元）时，这一信息并没有进一步削弱HYD选择，这已经很低了。HYD需求弹性仅增加了4美元，而没有HYD补充的替代方案为2美元。总之，阿片类药物寻求行为受到同时使用非药物和药物替代品的影响。这些发现表明，药物的可用性和非药物替代品相互作用，以调节药物寻求行为。
This study investigated the extent to which hydromorphone (HYD) choice and behavioral economic demand were influenced by HYD unit price (UP), alternative money reinforcement magnitude and post-session HYD supply. Heroin dependent research volunteers (n=13) stabilized on buprenorphine 8 mg/day first sampled two HYD doses (12 and 24 mg IM, labeled Drug A [session 1] and Drug B [session 2]). In each of the final six sessions, volunteers were given access to a 12-trial choice progressive ratio (PR) task and could earn a HYD unit dose (2 mg, fixed) or money ($2 or $4, varied across sessions), administered immediately after the work session. Before the PR task, volunteers were told which HYD supplemental dose (none, Drug A or B) would be available 3 hr after receiving the PR-contingent dose. PR-contingent HYD choice significantly decreased when $4 relative to $2 was concurrently available. Information about the post-session HYD supplement moderated this effect: when subjects were told a supplemental dose was available, HYD-seeking behavior decreased when the money alternative was smaller ($2), but this information did not further attenuate HYD choice, which was already low, when the money alternative was higher ($4). HYD demand elasticity was only increased by the $4 relative to $2 alternative without the HYD supplement. In summary, opioid-seeking behavior is influenced by the availability of concurrent non-drug and drug alternatives. These findings show that drug availability and non-drug alternatives interact to modulate drug-seeking behavior.
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影响因子：
3.9
作者：
Amass, L;Bickel, WK;Badger, GJ
通讯作者：
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