Fronto-temporal spontaneous resting state functional connectivity in pediatric bipolar disorder.
Fronto-temporal spontaneous resting state functional connectivity in pediatric bipolar disorder.
复制标题
DOI：
10.1016/j.biopsych.2010.06.029
复制
发表时间：
2010-11-01
影响因子：
10.6
通讯作者：
Milham, Michael P.
中科院分区：
文献类型：
--
作者：
Dickstein, Daniel P.;Gorrostieta, Cristina;Ombao, Hernando;Goldberg, Lisa D.;Brazel, Alison C.;Gable, Christopher J.;Kelly, Clare;Gee, Dylan G.;Zuo, Xi-Nian;Castellanos, F. Xavier;Milham, Michael P.
The recent upsurge in interest about pediatric bipolar disorder (BD) has spurred the need for greater understanding of its neurobiology. Structural and functional magnetic resonance imaging (MRI) studies have implicated fronto-temporal dysfunction in pediatric BD. However, recent data suggest that task-dependent neural changes account for a small fraction of the brain’s energy consumption. We now report the first use of task-independent spontaneous resting state functional connectivity (RSFC) to study the neural underpinnings of pediatric BD. We acquired a task-independent RSFC blood oxygen level-dependent fMRI scans while participants were at rest and also a high-resolution anatomical image (both at 3 Tesla) in BD and control youths (N=15 of each). Based on prior research, we focused on the left dorsolateral prefrontal cortex (DLPFC), amygdala, and accumbens. Image processing and group-level analyses followed that of prior work. Our primary analysis showed that pediatric BD participants had significantly greater negative RSFC between the left DLPFC and the right superior temporal gyrus (STG) versus controls. Secondary analyses using partial correlation showed that BD and control youths had opposite phase relationships between spontaneous RSFC fluctuations in the left DLPFC and right STG. Our data indicate that pediatric BD is characterized by altered task-independent functional connectivity in a fronto-temporal circuit that is also implicated in working memory and learning. Further study is warranted to determine the effects of age, sex, development, and treatment on this circuit in pediatric BD.
登录
查看更多内容
DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
--
作者：
Blumberg, HP;Kaufman, J;Peterson, BS
通讯作者：
Peterson, BS
影响因子：
5.4
作者：
Adler, CM;Holland, SK;Strakowski, SM
通讯作者：
Strakowski, SM
影响因子：
2.5
作者：
Chen, HH;Nicoletti, MA;Soares, JC
通讯作者：
Soares, JC
影响因子：
5.4
作者：
Bearden, Carrie E.;Glahn, David C.;Soares, Jair C.
通讯作者：
Soares, Jair C.