Selective luminal absorption of L-carnitine from the proximal regions of the rat epididymis. Possible relationships to development of sperm motility.

Selective luminal absorption of L-carnitine from the proximal regions of the rat epididymis. Possible relationships to development of sperm motility.
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大鼠附睾近端区域左旋肉碱的选择性腔内吸收。

DOI:
10.1002/j.1939-4640.1985.tb00849.x
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发表时间:
1985
影响因子:
--
通讯作者:
Hernandez,H
Hernandez,H
中科院分区:
--
文献类型:
--
作者:
Hinton,BT;Hernandez,H

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参考文献

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使用停流、分裂液滴微灌注技术研究了大鼠附睾近端区域导管对L-肉碱的吸收。通过时间依赖性和饱和转运系统(Km= 25 μm; Vmax= 0.65 pmoles吸收/min/mm 3小管体积)从附睾头近端的导管吸收L-肉碱。此外,吸收似乎主要是钠非依赖性的,尽管不能排除存在次要的钠依赖性途径。类似的转运系统沿附睾远端头沿着不明显,其中L-肉碱的吸收仅归因于被动扩散。L-肉毒碱穿过近端和远端附睾头上皮的向内和向外运动似乎受到调节,使得精子与远端头区域的高水平L-肉毒碱接触。
The absorption of L‐carnitine from the duct of the proximal regions of the rat epididymis was investigated using a stopped‐flow, split‐droplet microperfusion technique. L‐carnitine was absorbed from the duct of the proximal caput epididymidis by a time‐dependent and saturable transport system (Km= 25 μm; Vmax= 0.65 pmoles absorbed/min/mm3tubular volume). Furthermore, absorption appeared to be primarily sodium‐independent, although the existence of a minor sodium‐dependent pathway cannot be ruled out. A similar transport system was not evident along the distal caput epididymidis, where absorption of L‐carnitine was attributable to passive diffusion only. The inward and outward movement of L‐carnitine across the epithelium of the proximal and distal caput epididymidis appears to be regulated so that the spermatozoa come into contact with high levels of L‐carnitine in the distal caput region.
DOI: --
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期刊: The Anatomical Record
影响因子: --
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影响因子: 4.8
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